1iau

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[[Image:1iau.gif|left|200px]]
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{{Seed}}
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[[Image:1iau.png|left|200px]]
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{{STRUCTURE_1iau| PDB=1iau | SCENE= }}
{{STRUCTURE_1iau| PDB=1iau | SCENE= }}
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'''HUMAN GRANZYME B IN COMPLEX WITH AC-IEPD-CHO'''
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===HUMAN GRANZYME B IN COMPLEX WITH AC-IEPD-CHO===
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==Overview==
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BACKGROUND: Granzyme B, one of the most abundant granzymes in cytotoxic T-lymphocyte (CTL) granules, and members of the caspase (cysteine aspartyl proteinases) family have a unique cleavage specificity for aspartic acid in P1 and play critical roles in the biochemical events that culminate in cell death. RESULTS: We have determined the three-dimensional structure of the complex of the human granzyme B with a potent tetrapeptide aldehyde inhibitor. The Asp-specific S1 subsite of human granzyme B is significantly larger and less charged than the corresponding Asp-specific site in the apoptosis-promoting caspases, and also larger than the corresponding subsite in rat granzyme B. CONCLUSIONS: The above differences account for the variation in substrate specificity among granzyme B, other serine proteases and the caspases, and enable the design of specific inhibitors that can probe the physiological functions of these proteins and the disease states with which they are associated.
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The line below this paragraph, {{ABSTRACT_PUBMED_11325591}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11325591 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11325591}}
==About this Structure==
==About this Structure==
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[[Category: Willoughby, C A.]]
[[Category: Willoughby, C A.]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:47:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:41:10 2008''

Revision as of 07:41, 1 July 2008

Image:1iau.png

Template:STRUCTURE 1iau

HUMAN GRANZYME B IN COMPLEX WITH AC-IEPD-CHO

Template:ABSTRACT PUBMED 11325591

About this Structure

1IAU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1., Rotonda J, Garcia-Calvo M, Bull HG, Geissler WM, McKeever BM, Willoughby CA, Thornberry NA, Becker JW, Chem Biol. 2001 Apr;8(4):357-68. PMID:11325591

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