1iaw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1iaw.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1iaw.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1iaw| PDB=1iaw | SCENE= }}
{{STRUCTURE_1iaw| PDB=1iaw | SCENE= }}
-
'''CRYSTAL STRUCTURE OF NAEI COMPLEXED WITH 17MER DNA'''
+
===CRYSTAL STRUCTURE OF NAEI COMPLEXED WITH 17MER DNA===
-
==Overview==
+
<!--
-
NaeI, a novel DNA endonuclease, shows topoisomerase and recombinase activities when a Lys residue is substituted for Leu 43. The NaeI-DNA structure demonstrates that each of the two domains of NaeI recognizes one molecule of DNA duplex. DNA recognition induces dramatic rearrangements: narrowing the binding site of the Topo domain 16 A to grip DNA, widening that of the Endo domain 8 A to encircle and bend DNA 45 degrees for cleavage, and completely rebuilding the homodimer interface. The NaeI-DNA structure presents the first example of novel recognition of two copies of one DNA sequence by two different amino acid sequences and two different structural motifs in one polypeptide.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11473254}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11473254 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11473254}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Topal, M D.]]
[[Category: Topal, M D.]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:47:08 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:41:12 2008''

Revision as of 07:41, 1 July 2008

Image:1iaw.png

Template:STRUCTURE 1iaw

CRYSTAL STRUCTURE OF NAEI COMPLEXED WITH 17MER DNA

Template:ABSTRACT PUBMED 11473254

About this Structure

1IAW is a Single protein structure of sequence from Lechevalieria aerocolonigenes. Full crystallographic information is available from OCA.

Reference

Structure of NaeI-DNA complex reveals dual-mode DNA recognition and complete dimer rearrangement., Huai Q, Colandene JD, Topal MD, Ke H, Nat Struct Biol. 2001 Aug;8(8):665-9. PMID:11473254

Page seeded by OCA on Tue Jul 1 10:41:12 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1iaw"
Personal tools