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1iay

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{{STRUCTURE_1iay| PDB=1iay | SCENE= }}
{{STRUCTURE_1iay| PDB=1iay | SCENE= }}
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'''CRYSTAL STRUCTURE OF ACC SYNTHASE COMPLEXED WITH COFACTOR PLP AND INHIBITOR AVG'''
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===CRYSTAL STRUCTURE OF ACC SYNTHASE COMPLEXED WITH COFACTOR PLP AND INHIBITOR AVG===
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==Overview==
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The structures of tomato 1-aminocyclopropane-1-carboxylate synthase (ACS) in complex with either cofactor pyridoxal-5'-phosphate (PLP) or both PLP and inhibitor aminoethoxyvinylglycine have been determined by x-ray crystallography. The structures showed good conservation of the catalytic residues, suggesting a similar catalytic mechanism for ACS and other PLP-dependent enzymes. However, the proximity of Tyr152 to the C-gamma-S bond of model substrate S-adenosylmethionine implies its critical role in the catalysis. The concerted accomplishment of catalysis by cofactor PLP and a protein residue, as proposed on the basis of the ACS structures in this paper, may represent a general scheme for the diversity of PLP-dependent catalyses. PLP-dependent enzymes have been categorized into four types of folds. A structural comparison revealed that a core fragment of ACS in fold type I is superimposable over tryptophan synthase beta subunit in fold type II and mouse ornithine decarboxylase in fold type III, thus suggesting a divergent evolution of PLP-dependent enzymes.
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(as it appears on PubMed at http://www.pubmed.gov), where 11431475 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11431475}}
==About this Structure==
==About this Structure==
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[[Category: Protein-cofactor-inhibitor complex]]
[[Category: Protein-cofactor-inhibitor complex]]
[[Category: V6-dependent enzyme]]
[[Category: V6-dependent enzyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:41:24 2008''

Revision as of 07:41, 1 July 2008

Image:1iay.png

Template:STRUCTURE 1iay

CRYSTAL STRUCTURE OF ACC SYNTHASE COMPLEXED WITH COFACTOR PLP AND INHIBITOR AVG

Template:ABSTRACT PUBMED 11431475

About this Structure

1IAY is a Single protein structure of sequence from Solanum lycopersicum. Full crystallographic information is available from OCA.

Reference

Crystal structures of 1-aminocyclopropane-1-carboxylate (ACC) synthase in complex with aminoethoxyvinylglycine and pyridoxal-5'-phosphate provide new insight into catalytic mechanisms., Huai Q, Xia Y, Chen Y, Callahan B, Li N, Ke H, J Biol Chem. 2001 Oct 12;276(41):38210-6. Epub 2001 Jun 28. PMID:11431475

Page seeded by OCA on Tue Jul 1 10:41:24 2008

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