1ibo

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[[Image:1ibo.gif|left|200px]]
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{{STRUCTURE_1ibo| PDB=1ibo | SCENE= }}
{{STRUCTURE_1ibo| PDB=1ibo | SCENE= }}
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'''NMR STRUCTURE OF HEMAGGLUTININ FUSION PEPTIDE IN DPC MICELLES AT PH 7.4'''
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===NMR STRUCTURE OF HEMAGGLUTININ FUSION PEPTIDE IN DPC MICELLES AT PH 7.4===
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==Overview==
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The N-terminal domain of the influenza hemagglutinin (HA) is the only portion of the molecule that inserts deeply into membranes of infected cells to mediate the viral and the host cell membrane fusion. This domain constitutes an autonomous folding unit in the membrane, causes hemolysis of red blood cells and catalyzes lipid exchange between juxtaposed membranes in a pH-dependent manner. Combining NMR structures determined at pHs 7.4 and 5 with EPR distance constraints, we have deduced the structures of the N-terminal domain of HA in the lipid bilayer. At both pHs, the domain is a kinked, predominantly helical amphipathic structure. At the fusogenic pH 5, however, the domain has a sharper bend, an additional 3(10)-helix and a twist, resulting in the repositioning of Glu 15 and Asp 19 relative to that at the nonfusogenic pH 7.4. Rotation of these charged residues out of the membrane plane creates a hydrophobic pocket that allows a deeper insertion of the fusion domain into the core of the lipid bilayer. Such an insertion mode could perturb lipid packing and facilitate lipid mixing between juxtaposed membranes.
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(as it appears on PubMed at http://www.pubmed.gov), where 11473264 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11473264}}
==About this Structure==
==About this Structure==
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1IBO is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IBO OCA].
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1IBO is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IBO OCA].
==Reference==
==Reference==
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[[Category: Tamm, L K.]]
[[Category: Tamm, L K.]]
[[Category: Helix-kink-irregular]]
[[Category: Helix-kink-irregular]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:48:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:43:21 2008''

Revision as of 07:43, 1 July 2008

Image:1ibo.png

Template:STRUCTURE 1ibo

NMR STRUCTURE OF HEMAGGLUTININ FUSION PEPTIDE IN DPC MICELLES AT PH 7.4

Template:ABSTRACT PUBMED 11473264

About this Structure

1IBO is a Single protein structure. Full experimental information is available from OCA.

Reference

Membrane structure and fusion-triggering conformational change of the fusion domain from influenza hemagglutinin., Han X, Bushweller JH, Cafiso DS, Tamm LK, Nat Struct Biol. 2001 Aug;8(8):715-20. PMID:11473264

Page seeded by OCA on Tue Jul 1 10:43:21 2008

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