1ibx

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{{STRUCTURE_1ibx| PDB=1ibx | SCENE= }}
{{STRUCTURE_1ibx| PDB=1ibx | SCENE= }}
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'''NMR STRUCTURE OF DFF40 AND DFF45 N-TERMINAL DOMAIN COMPLEX'''
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===NMR STRUCTURE OF DFF40 AND DFF45 N-TERMINAL DOMAIN COMPLEX===
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==Overview==
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Apoptotic DNA fragmentation is mediated by a caspase-activated DNA fragmentation factor (DFF)40. Expression and folding of DFF40 require the presence of DFF45, which also acts as a nuclease inhibitor before DFF40 activation by execution caspases. The N-terminal domains (NTDs) of both proteins are homologous, and their interaction plays a key role in the proper functioning of this two-component system. Here we report that the NTD of DFF45 alone is unstructured in solution, and its folding is induced upon binding to DFF40 NTD. Therefore, folding of both proteins regulates the formation of the DFF40/DFF45 complex. The solution structure of the heterodimeric complex between NTDs of DFF40 and DFF45 reported here shows that the mutual chaperoning includes the formation of an extensive network of intermolecular interactions that bury a hydrophobic cluster inside the interface, surrounded by intermolecular salt bridges.
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The line below this paragraph, {{ABSTRACT_PUBMED_11371636}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11371636 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11371636}}
==About this Structure==
==About this Structure==
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1IBX is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Streptococcus_sp._and_homo_sapiens Streptococcus sp. and homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IBX OCA].
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1IBX is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Streptococcus_sp._and_homo_sapiens Streptococcus sp. and homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IBX OCA].
==Reference==
==Reference==
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[[Category: Dff45]]
[[Category: Dff45]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:49:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:44:06 2008''

Revision as of 07:44, 1 July 2008

Image:1ibx.png

Template:STRUCTURE 1ibx

NMR STRUCTURE OF DFF40 AND DFF45 N-TERMINAL DOMAIN COMPLEX

Template:ABSTRACT PUBMED 11371636

About this Structure

1IBX is a Protein complex structure of sequences from Homo sapiens and Streptococcus sp. and homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45., Zhou P, Lugovskoy AA, McCarty JS, Li P, Wagner G, Proc Natl Acad Sci U S A. 2001 May 22;98(11):6051-5. PMID:11371636

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