1ic8

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[[Image:1ic8.gif|left|200px]]
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{{STRUCTURE_1ic8| PDB=1ic8 | SCENE= }}
{{STRUCTURE_1ic8| PDB=1ic8 | SCENE= }}
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'''HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT'''
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===HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT===
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==Overview==
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Mutations in Hnf-1alpha are the most common Mendelian cause of diabetes mellitus. To elucidate the molecular function of a mutational hotspot, we cocrystallized human HNF-1alpha 83-279 with a high-affinity promoter and solved the structure of the complex. Two identical protein molecules are bound to the promoter. Each contains a homeodomain and a second domain structurally similar to POU-specific domains that was not predicted on the basis of amino acid sequence. Atypical elements in both domains create a stable interface that further distinguishes HNF-1alpha from other flexible POU-homeodomain proteins. The numerous diabetes-causing mutations in HNF-1alpha thus identified a previously unrecognized POU domain which was used as a search model to identify additional POU domain proteins in sequence databases.
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(as it appears on PubMed at http://www.pubmed.gov), where 12453420 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12453420}}
==About this Structure==
==About this Structure==
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[[Category: Pou domain]]
[[Category: Pou domain]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:50:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:45:05 2008''

Revision as of 07:45, 1 July 2008

Image:1ic8.png

Template:STRUCTURE 1ic8

HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT

Template:ABSTRACT PUBMED 12453420

About this Structure

1IC8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Diabetes mutations delineate an atypical POU domain in HNF-1alpha., Chi YI, Frantz JD, Oh BC, Hansen L, Dhe-Paganon S, Shoelson SE, Mol Cell. 2002 Nov;10(5):1129-37. PMID:12453420

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