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1ici

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[[Image:1ici.gif|left|200px]]
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{{STRUCTURE_1ici| PDB=1ici | SCENE= }}
{{STRUCTURE_1ici| PDB=1ici | SCENE= }}
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'''CRYSTAL STRUCTURE OF A SIR2 HOMOLOG-NAD COMPLEX'''
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===CRYSTAL STRUCTURE OF A SIR2 HOMOLOG-NAD COMPLEX===
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==Overview==
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The SIR2 protein family comprises a novel class of nicotinamide-adenine dinucleotide (NAD)-dependent protein deacetylases that function in transcriptional silencing, DNA repair, and life-span extension in Saccharomyces cerevisiae. Two crystal structures of a SIR2 homolog from Archaeoglobus fulgidus complexed with NAD have been determined at 2.1 A and 2.4 A resolutions. The structures reveal that the protein consists of a large domain having a Rossmann fold and a small domain containing a three-stranded zinc ribbon motif. NAD is bound in a pocket between the two domains. A distinct mode of NAD binding and an unusual configuration of the zinc ribbon motif are observed. The structures also provide important insights into the catalytic mechanism of NAD-dependent protein deacetylation by this family of enzymes.
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(as it appears on PubMed at http://www.pubmed.gov), where 11336676 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11336676}}
==About this Structure==
==About this Structure==
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[[Category: Rossmann fold]]
[[Category: Rossmann fold]]
[[Category: Zinc ribbon]]
[[Category: Zinc ribbon]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:45:36 2008''

Revision as of 07:45, 1 July 2008

Image:1ici.png

Template:STRUCTURE 1ici

CRYSTAL STRUCTURE OF A SIR2 HOMOLOG-NAD COMPLEX

Template:ABSTRACT PUBMED 11336676

About this Structure

1ICI is a Single protein structure of sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a SIR2 homolog-NAD complex., Min J, Landry J, Sternglanz R, Xu RM, Cell. 2001 Apr 20;105(2):269-79. PMID:11336676

Page seeded by OCA on Tue Jul 1 10:45:36 2008

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