1ico

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[[Image:1ico.jpg|left|200px]]
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{{Seed}}
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[[Image:1ico.png|left|200px]]
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{{STRUCTURE_1ico| PDB=1ico | SCENE= }}
{{STRUCTURE_1ico| PDB=1ico | SCENE= }}
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'''SOLUTION STRUCTURE OF DESIGNED BETA-SHEET MINI-PROTEIN TH10BOX'''
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===SOLUTION STRUCTURE OF DESIGNED BETA-SHEET MINI-PROTEIN TH10BOX===
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==Overview==
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Here we report the creation of a predominantly beta-structured mini-protein motif. The design target is based on the naturally occurring toxin hand (TH) motifs that are composed of four disulfide bonds and three loops that form a 'hand'. Analysis and subsequent modification of several generations of mini-proteins produced the final 29-residue mini-protein. The structured motif of this new mini-protein provides insight into the compensatory changes that result in the formation of a tightly packed hydrophobic core in a small, globular beta-structure motif. Additionally, this mini-motif represents a new, distinct surface topology for protein design and a valuable, yet compact, model system for the study of beta-sheet structure in water.
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The line below this paragraph, {{ABSTRACT_PUBMED_11373623}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11373623 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11373623}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICO OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICO OCA].
==Reference==
==Reference==
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[[Category: Ottesen, J J.]]
[[Category: Ottesen, J J.]]
[[Category: De novo protein design three-stranded beta-sheet mini-protein motif th motif]]
[[Category: De novo protein design three-stranded beta-sheet mini-protein motif th motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:50:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:45:56 2008''

Revision as of 07:45, 1 July 2008

Image:1ico.png

Template:STRUCTURE 1ico

SOLUTION STRUCTURE OF DESIGNED BETA-SHEET MINI-PROTEIN TH10BOX

Template:ABSTRACT PUBMED 11373623

About this Structure

Full experimental information is available from OCA.

Reference

Design of a discretely folded mini-protein motif with predominantly beta-structure., Ottesen JJ, Imperiali B, Nat Struct Biol. 2001 Jun;8(6):535-9. PMID:11373623

Page seeded by OCA on Tue Jul 1 10:45:56 2008

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