1id3

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{{STRUCTURE_1id3| PDB=1id3 | SCENE= }}
{{STRUCTURE_1id3| PDB=1id3 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE YEAST NUCLEOSOME CORE PARTICLE REVEALS FUNDAMENTAL DIFFERENCES IN INTER-NUCLEOSOME INTERACTIONS'''
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===CRYSTAL STRUCTURE OF THE YEAST NUCLEOSOME CORE PARTICLE REVEALS FUNDAMENTAL DIFFERENCES IN INTER-NUCLEOSOME INTERACTIONS===
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==Overview==
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Chromatin is composed of nucleosomes, the universally repeating protein-DNA complex in eukaryotic cells. The crystal structure of the nucleosome core particle from Saccharomyces cerevisiae reveals that the structure and function of this fundamental complex is conserved between single-cell organisms and metazoans. Our results show that yeast nucleosomes are likely to be subtly destabilized as compared with nucleosomes from higher eukaryotes, consistent with the idea that much of the yeast genome remains constitutively open during much of its life cycle. Importantly, minor sequence variations lead to dramatic changes in the way in which nucleosomes pack against each other within the crystal lattice. This has important implications for our understanding of the formation of higher order chromatin structure and its modulation by post-translational modifications. Finally, the yeast nucleosome core particle provides a structural context by which to interpret genetic data obtained from yeast. Coordinates have been deposited with the Protein Data Bank under accession number 1ID3.
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{{ABSTRACT_PUBMED_11566884}}
==About this Structure==
==About this Structure==
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[[Category: Protein/dna interaction]]
[[Category: Protein/dna interaction]]
[[Category: Supercoiled dna]]
[[Category: Supercoiled dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:51:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:47:03 2008''

Revision as of 07:47, 1 July 2008

Image:1id3.png

Template:STRUCTURE 1id3

CRYSTAL STRUCTURE OF THE YEAST NUCLEOSOME CORE PARTICLE REVEALS FUNDAMENTAL DIFFERENCES IN INTER-NUCLEOSOME INTERACTIONS

Template:ABSTRACT PUBMED 11566884

About this Structure

1ID3 is a Protein complex structure of sequences from Homo sapiens and Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of the yeast nucleosome core particle reveals fundamental changes in internucleosome interactions., White CL, Suto RK, Luger K, EMBO J. 2001 Sep 17;20(18):5207-18. PMID:11566884

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