1ieb

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[[Image:1ieb.gif|left|200px]]
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{{Seed}}
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[[Image:1ieb.png|left|200px]]
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{{STRUCTURE_1ieb| PDB=1ieb | SCENE= }}
{{STRUCTURE_1ieb| PDB=1ieb | SCENE= }}
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'''HISTOCOMPATIBILITY ANTIGEN'''
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===HISTOCOMPATIBILITY ANTIGEN===
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==Overview==
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The high-resolution x-ray crystal structures of the murine major histocompatibility complex (MHC) class II molecule, I-E(k), occupied by either of two antigenic peptides were determined. They reveal the structural basis for the I-E(k) peptide binding motif and suggest general principles for additional alleles. A buried cluster of acidic amino acids in the binding groove predicted to be conserved among all murine I-E and human DR MHC class II molecules suggests how pH may influence MHC binding or exchange of peptides. These structures also complement mutational studies on the importance of individual peptide residues to T cell receptor recognition.
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The line below this paragraph, {{ABSTRACT_PUBMED_8638119}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8638119 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8638119}}
==About this Structure==
==About this Structure==
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[[Category: Marrack, P.]]
[[Category: Marrack, P.]]
[[Category: Histocompatibility antigen]]
[[Category: Histocompatibility antigen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:54:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:50:21 2008''

Revision as of 07:50, 1 July 2008

Image:1ieb.png

Template:STRUCTURE 1ieb

HISTOCOMPATIBILITY ANTIGEN

Template:ABSTRACT PUBMED 8638119

About this Structure

1IEB is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structures of an MHC class II molecule with covalently bound single peptides., Fremont DH, Hendrickson WA, Marrack P, Kappler J, Science. 1996 May 17;272(5264):1001-4. PMID:8638119

Page seeded by OCA on Tue Jul 1 10:50:21 2008

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