1if0

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[[Image:1if0.gif|left|200px]]
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{{Seed}}
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[[Image:1if0.png|left|200px]]
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{{STRUCTURE_1if0| PDB=1if0 | SCENE= }}
{{STRUCTURE_1if0| PDB=1if0 | SCENE= }}
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'''PSEUDO-ATOMIC MODEL OF BACTERIOPHAGE HK97 PROCAPSID (PROHEAD II)'''
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===PSEUDO-ATOMIC MODEL OF BACTERIOPHAGE HK97 PROCAPSID (PROHEAD II)===
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==Overview==
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Large-scale conformational changes transform viral precursors into infectious virions. The structure of bacteriophage HK97 capsid, Head-II, was recently solved by crystallography, revealing a catenated cross-linked topology. We have visualized its precursor, Prohead-II, by cryoelectron microscopy and modeled the conformational change by appropriately adapting Head-II. Rigid-body rotations ( approximately 40 degrees) cause switching to an entirely different set of interactions; in addition, two motifs undergo refolding. These changes stabilize the capsid by increasing the surface area buried at interfaces and bringing the cross-link-forming residues, initially approximately 40 angstroms apart, close together. The inner surface of Prohead-II is negatively charged, suggesting that the transition is triggered electrostatically by DNA packaging.
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The line below this paragraph, {{ABSTRACT_PUBMED_11326105}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11326105 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11326105}}
==About this Structure==
==About this Structure==
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[[Category: Pseudo-atomic model.]]
[[Category: Pseudo-atomic model.]]
[[Category: Virus]]
[[Category: Virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:55:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:52:12 2008''

Revision as of 07:52, 1 July 2008

Image:1if0.png

Template:STRUCTURE 1if0

PSEUDO-ATOMIC MODEL OF BACTERIOPHAGE HK97 PROCAPSID (PROHEAD II)

Template:ABSTRACT PUBMED 11326105

About this Structure

1IF0 is a Single protein structure of sequence from Enterobacteria phage hk97. Full crystallographic information is available from OCA.

Reference

Virus maturation involving large subunit rotations and local refolding., Conway JF, Wikoff WR, Cheng N, Duda RL, Hendrix RW, Johnson JE, Steven AC, Science. 2001 Apr 27;292(5517):744-8. PMID:11326105

Page seeded by OCA on Tue Jul 1 10:52:12 2008

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