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1if1

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[[Image:1if1.gif|left|200px]]
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{{Seed}}
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[[Image:1if1.png|left|200px]]
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{{STRUCTURE_1if1| PDB=1if1 | SCENE= }}
{{STRUCTURE_1if1| PDB=1if1 | SCENE= }}
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'''INTERFERON REGULATORY FACTOR 1 (IRF-1) COMPLEX WITH DNA'''
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===INTERFERON REGULATORY FACTOR 1 (IRF-1) COMPLEX WITH DNA===
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==Overview==
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The family of interferon regulatory factor (IRF) transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Here we report the crystal structure of the IRF-1 region bound to the natural positive regulatory domain I (PRD I) DNA element from the interferon-beta promoter. The structure provides the first three-dimensional view of a member of the growing IRF family, revealing a new helix-turn-helix motif that latches onto DNA through three of the five conserved tryptophans. The motif selects a short GAAA core sequence through an obliquely angled recognition helix, with an accompanying bending of the DNA axis in the direction of the protein. Together, these features suggest a basis for the occurrence of GAAA repeats within IRF response elements and provide clues to the assembly of the higher-order interferon-beta enhancesome.
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The line below this paragraph, {{ABSTRACT_PUBMED_9422515}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9422515 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9422515}}
==About this Structure==
==About this Structure==
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[[Category: Interferon regulation]]
[[Category: Interferon regulation]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:55:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:52:20 2008''

Revision as of 07:52, 1 July 2008

Image:1if1.png

Template:STRUCTURE 1if1

INTERFERON REGULATORY FACTOR 1 (IRF-1) COMPLEX WITH DNA

Template:ABSTRACT PUBMED 9422515

About this Structure

1IF1 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of IRF-1 with bound DNA reveals determinants of interferon regulation., Escalante CR, Yie J, Thanos D, Aggarwal AK, Nature. 1998 Jan 1;391(6662):103-6. PMID:9422515

Page seeded by OCA on Tue Jul 1 10:52:20 2008

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