1ifq

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{{STRUCTURE_1ifq| PDB=1ifq | SCENE= }}
{{STRUCTURE_1ifq| PDB=1ifq | SCENE= }}
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'''Sec22b N-terminal domain'''
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===Sec22b N-terminal domain===
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==Overview==
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Intra-cellular membrane fusion is facilitated by the association of SNAREs from opposite membranes into stable alpha-helical bundles. Many SNAREs, in addition to their alpha-helical regions, contain N-terminal domains that likely have essential regulatory functions. To better understand this regulation, we have determined the 2.4-A crystal structure of the 130-amino acid N-terminal domain of mouse Sec22b (mSec22b), a SNARE involved in endoplasmic reticulum/Golgi membrane trafficking. The domain consists of a mixed alpha-helical/beta-sheet fold that resembles a circular permutation of the actin/poly-proline binding protein, profilin, and the GAF/PAS family of regulatory modules. The structure is distinct from the previously characterized N-terminal domain of syntaxin 1A, and, unlike syntaxin 1A, the N-terminal domain of mSec22b has no effect on the rate of SNARE assembly in vitro. An analysis of surface conserved residues reveals a potential protein interaction site. Key residues in this site are distinct in two mammalian Sec22 variants that lack SNARE domains. Finally, sequence analysis indicates that a similar domain is likely present in the endosomal/lysosomal SNARE VAMP7.
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The line below this paragraph, {{ABSTRACT_PUBMED_11309394}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11309394 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11309394}}
==About this Structure==
==About this Structure==
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[[Category: Alpha/beta 3-layer sandwich]]
[[Category: Alpha/beta 3-layer sandwich]]
[[Category: Five-stranded anti-parallel beta sheet]]
[[Category: Five-stranded anti-parallel beta sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:57:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:53:45 2008''

Revision as of 07:53, 1 July 2008

Image:1ifq.png

Template:STRUCTURE 1ifq

Sec22b N-terminal domain

Template:ABSTRACT PUBMED 11309394

About this Structure

1IFQ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

A novel snare N-terminal domain revealed by the crystal structure of Sec22b., Gonzalez LC Jr, Weis WI, Scheller RH, J Biol Chem. 2001 Jun 29;276(26):24203-11. Epub 2001 Apr 17. PMID:11309394

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