This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ifq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ifq.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1ifq.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ifq| PDB=1ifq | SCENE= }}
{{STRUCTURE_1ifq| PDB=1ifq | SCENE= }}
-
'''Sec22b N-terminal domain'''
+
===Sec22b N-terminal domain===
-
==Overview==
+
<!--
-
Intra-cellular membrane fusion is facilitated by the association of SNAREs from opposite membranes into stable alpha-helical bundles. Many SNAREs, in addition to their alpha-helical regions, contain N-terminal domains that likely have essential regulatory functions. To better understand this regulation, we have determined the 2.4-A crystal structure of the 130-amino acid N-terminal domain of mouse Sec22b (mSec22b), a SNARE involved in endoplasmic reticulum/Golgi membrane trafficking. The domain consists of a mixed alpha-helical/beta-sheet fold that resembles a circular permutation of the actin/poly-proline binding protein, profilin, and the GAF/PAS family of regulatory modules. The structure is distinct from the previously characterized N-terminal domain of syntaxin 1A, and, unlike syntaxin 1A, the N-terminal domain of mSec22b has no effect on the rate of SNARE assembly in vitro. An analysis of surface conserved residues reveals a potential protein interaction site. Key residues in this site are distinct in two mammalian Sec22 variants that lack SNARE domains. Finally, sequence analysis indicates that a similar domain is likely present in the endosomal/lysosomal SNARE VAMP7.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11309394}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11309394 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11309394}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Alpha/beta 3-layer sandwich]]
[[Category: Alpha/beta 3-layer sandwich]]
[[Category: Five-stranded anti-parallel beta sheet]]
[[Category: Five-stranded anti-parallel beta sheet]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:57:03 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:53:45 2008''

Revision as of 07:53, 1 July 2008

Image:1ifq.png

Template:STRUCTURE 1ifq

Sec22b N-terminal domain

Template:ABSTRACT PUBMED 11309394

About this Structure

1IFQ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

A novel snare N-terminal domain revealed by the crystal structure of Sec22b., Gonzalez LC Jr, Weis WI, Scheller RH, J Biol Chem. 2001 Jun 29;276(26):24203-11. Epub 2001 Apr 17. PMID:11309394

Page seeded by OCA on Tue Jul 1 10:53:45 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ifq"
Personal tools