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1ig1

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[[Image:1ig1.gif|left|200px]]
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{{STRUCTURE_1ig1| PDB=1ig1 | SCENE= }}
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'''1.8A X-Ray structure of ternary complex of a catalytic domain of death-associated protein kinase with ATP analogue and Mn.'''
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===1.8A X-Ray structure of ternary complex of a catalytic domain of death-associated protein kinase with ATP analogue and Mn.===
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==Overview==
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We have determined X-ray crystal structures with up to 1.5 A resolution of the catalytic domain of death-associated protein kinase (DAPK), the first described member of a novel family of pro-apoptotic and tumor-suppressive serine/threonine kinases. The geometry of the active site was studied in the apo form, in a complex with nonhydrolyzable AMPPnP and in a ternary complex consisting of kinase, AMPPnP and either Mg2+ or Mn2+. The structures revealed a previously undescribed water-mediated stabilization of the interaction between the lysine that is conserved in protein kinases and the beta- and gamma-phosphates of ATP, as well as conformational changes at the active site upon ion binding. Comparison between these structures and nucleotide triphosphate complexes of several other kinases disclosed a number of unique features of the DAPK catalytic domain, among which is a highly ordered basic loop in the N-terminal domain that may participate in enzyme regulation.
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The line below this paragraph, {{ABSTRACT_PUBMED_11573098}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11573098 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11573098}}
==About this Structure==
==About this Structure==
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[[Category: Watterson, D M.]]
[[Category: Watterson, D M.]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:57:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:55:55 2008''

Revision as of 07:56, 1 July 2008

Image:1ig1.png

Template:STRUCTURE 1ig1

1.8A X-Ray structure of ternary complex of a catalytic domain of death-associated protein kinase with ATP analogue and Mn.

Template:ABSTRACT PUBMED 11573098

About this Structure

1IG1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression., Tereshko V, Teplova M, Brunzelle J, Watterson DM, Egli M, Nat Struct Biol. 2001 Oct;8(10):899-907. PMID:11573098

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