1igb

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{{STRUCTURE_1igb| PDB=1igb | SCENE= }}
{{STRUCTURE_1igb| PDB=1igb | SCENE= }}
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'''AEROMONAS PROTEOLYTICA AMINOPEPTIDASE COMPLEXED WITH THE INHIBITOR PARA-IODO-D-PHENYLALANINE HYDROXAMATE'''
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===AEROMONAS PROTEOLYTICA AMINOPEPTIDASE COMPLEXED WITH THE INHIBITOR PARA-IODO-D-PHENYLALANINE HYDROXAMATE===
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==Overview==
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The structure of the complex of Aeromonas proteolytica aminopeptidase, a two-zinc exopeptidase, with the inhibitor p-iodo-D-phenylalanine hydroxamate has been determined by X-ray crystallography. Refinement of the structure, which includes 220 water molecules, using data at 0.80-0.23-nm resolution resulted in a crystallographic residual R value of 16%. The hydroxamate group adopts a planar conformation whereby the two oxygen atoms interact with the zinc ions. The N-hydroxyl group of the inhibitor is located between the two zinc ions, a position which is close to that occupied by a water molecule in the native structure. The carbonyl oxygen of the inhibitor binds to Zn1, which becomes pentacoordinated while Zn2 remains tetracoordinated, in contrast to the native protein where both zinc ions were shown to be tetracoordinated and structurally equivalent. Interactions of the carboxylate oxygens of Glu151 with the hydroxamate group play an important role in the stabilization of the complex.
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{{ABSTRACT_PUBMED_8647077}}
==About this Structure==
==About this Structure==
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[[Category: Aminopeptidase]]
[[Category: Aminopeptidase]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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Revision as of 07:59, 1 July 2008

Image:1igb.png

Template:STRUCTURE 1igb

AEROMONAS PROTEOLYTICA AMINOPEPTIDASE COMPLEXED WITH THE INHIBITOR PARA-IODO-D-PHENYLALANINE HYDROXAMATE

Template:ABSTRACT PUBMED 8647077

About this Structure

1IGB is a Single protein structure of sequence from Vibrio proteolyticus. Full crystallographic information is available from OCA.

Reference

The structure of the Aeromonas proteolytica aminopeptidase complexed with a hydroxamate inhibitor. Involvement in catalysis of Glu151 and two zinc ions of the co-catalytic unit., Chevrier B, D'Orchymont H, Schalk C, Tarnus C, Moras D, Eur J Biochem. 1996 Apr 15;237(2):393-8. PMID:8647077

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