1igw

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{{STRUCTURE_1igw| PDB=1igw | SCENE= }}
{{STRUCTURE_1igw| PDB=1igw | SCENE= }}
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'''Crystal Structure of the Isocitrate Lyase from the A219C mutant of Escherichia coli'''
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===Crystal Structure of the Isocitrate Lyase from the A219C mutant of Escherichia coli===
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==Overview==
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Enzymes of the glyoxylate-bypass pathway are potential targets for the control of many human diseases caused by such pathogens as Mycobacteria and Leishmania. Isocitrate lyase catalyses the first committed step in this pathway and the structure of this tetrameric enzyme from Escherichia coli has been determined at 2.1 A resolution. E. coli isocitrate lyase, like the enzyme from other prokaryotes, is located in the cytoplasm, whereas in plants, protozoa, algae and fungi this enzyme is found localized in glyoxysomes. Comparison of the structure of the prokaryotic isocitrate lyase with that from the eukaryote Aspergillus nidulans reveals a different domain structure following the deletion of approximately 100 residues from the larger eukaryotic enzyme. Despite this, the active sites of the prokaryotic and eukaryotic enzymes are very closely related, including the apparent disorder of two equivalent segments of the protein that are known to be involved in a conformational change as part of the enzyme's catalytic cycle.
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The line below this paragraph, {{ABSTRACT_PUBMED_11526312}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11526312 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11526312}}
==About this Structure==
==About this Structure==
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[[Category: Weeradechapon, K.]]
[[Category: Weeradechapon, K.]]
[[Category: Beta barrel]]
[[Category: Beta barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:59:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 12:08:55 2008''

Revision as of 09:08, 1 July 2008

Image:1igw.png

Template:STRUCTURE 1igw

Crystal Structure of the Isocitrate Lyase from the A219C mutant of Escherichia coli

Template:ABSTRACT PUBMED 11526312

About this Structure

1IGW is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The structure and domain organization of Escherichia coli isocitrate lyase., Britton KL, Abeysinghe IS, Baker PJ, Barynin V, Diehl P, Langridge SJ, McFadden BA, Sedelnikova SE, Stillman TJ, Weeradechapon K, Rice DW, Acta Crystallogr D Biol Crystallogr. 2001 Sep;57(Pt 9):1209-18. Epub 2001, Aug 23. PMID:11526312

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