1ihb

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{{Seed}}
[[Image:1ihb.png|left|200px]]
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{{STRUCTURE_1ihb| PDB=1ihb | SCENE= }}
{{STRUCTURE_1ihb| PDB=1ihb | SCENE= }}
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'''CRYSTAL STRUCTURE OF P18-INK4C(INK6)'''
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===CRYSTAL STRUCTURE OF P18-INK4C(INK6)===
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==Overview==
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p18INK4c is a member of a family of INK4 proteins that function to arrest the G1 to S cell cycle transition by inhibiting the activity of the cyclin-dependent kinases 4 and 6. The X-ray crystal structure of the human p18INK4c protein to a resolution of 1.95 A reveals an elongated molecule comprised of five contiguous 32- or 33-residue ankyrin-like repeat units. Each ankyrin-like repeat contains a beta-strand helix-turn-helix extended strand beta-strand motif that associates with neighboring motifs through beta-sheet, and helical bundle interactions. Conserved ankyrin-like repeat residues function to facilitate the ankyrin repeat fold and the tertiary interactions between neighboring repeat units. A large percentage of residues that are conserved among INK4 proteins and that map to positions of tumor-derived p16INK4 mutations play important roles in protein stability. A subset of these residues suggest an INK4 binding surface for the cyclin-dependent kinases 4 and 6. This surface is centered around a region that shows structural features uncharacteristic of ankyrin-like repeat units.
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The line below this paragraph, {{ABSTRACT_PUBMED_9437433}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9437433 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9437433}}
==About this Structure==
==About this Structure==
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[[Category: Cell cycle inhibitor]]
[[Category: Cell cycle inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jun 24 23:22:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 12:11:01 2008''

Revision as of 09:11, 1 July 2008

Image:1ihb.png

Template:STRUCTURE 1ihb

CRYSTAL STRUCTURE OF P18-INK4C(INK6)

Template:ABSTRACT PUBMED 9437433

About this Structure

1IHB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations., Venkataramani R, Swaminathan K, Marmorstein R, Nat Struct Biol. 1998 Jan;5(1):74-81. PMID:9437433

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