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1ihj

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{{STRUCTURE_1ihj| PDB=1ihj | SCENE= }}
{{STRUCTURE_1ihj| PDB=1ihj | SCENE= }}
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'''Crystal Structure of the N-terminal PDZ domain of InaD in complex with a NorpA C-terminal peptide'''
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===Crystal Structure of the N-terminal PDZ domain of InaD in complex with a NorpA C-terminal peptide===
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==Overview==
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In Drosophila, phototransduction is mediated by G(q)-activation of phospholipase C and is a well studied model system for understanding the kinetics of signal initiation, propagation and termination controlled by G proteins. The proper intracellular targeting and spatial arrangement of most proteins involved in fly phototransduction require the multi-domain scaffolding protein InaD, composed almost entirely of five PDZ domains, which independently bind various proteins including NorpA, the relevant phospho lipase C-beta isozyme. We have determined the crystal structure of the N-terminal PDZ domain of InaD bound to a peptide corresponding to the C-terminus of NorpA to 1.8 A resolution. The structure highlights an intermolecular disulfide bond necessary for high affinity interaction as determined by both in vitro and in vivo studies. Since other proteins also possess similar, cysteine-containing consensus sequences for binding PDZ domains, this disulfide-mediated 'dock-and-lock' interaction of PDZ domains with their ligands may be a relatively ubiquitous mode of coordinating signaling pathways.
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The line below this paragraph, {{ABSTRACT_PUBMED_11500369}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11500369 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11500369}}
==About this Structure==
==About this Structure==
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[[Category: Intermolecular disulfide bond]]
[[Category: Intermolecular disulfide bond]]
[[Category: Pdz domain]]
[[Category: Pdz domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:00:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 12:11:46 2008''

Revision as of 09:11, 1 July 2008

Image:1ihj.png

Template:STRUCTURE 1ihj

Crystal Structure of the N-terminal PDZ domain of InaD in complex with a NorpA C-terminal peptide

Template:ABSTRACT PUBMED 11500369

About this Structure

1IHJ is a Protein complex structure of sequences from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Functional relevance of the disulfide-linked complex of the N-terminal PDZ domain of InaD with NorpA., Kimple ME, Siderovski DP, Sondek J, EMBO J. 2001 Aug 15;20(16):4414-22. PMID:11500369

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