1ihm

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[[Image:1ihm.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1ihm| PDB=1ihm | SCENE= }}
{{STRUCTURE_1ihm| PDB=1ihm | SCENE= }}
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'''CRYSTAL STRUCTURE ANALYSIS OF NORWALK VIRUS CAPSID'''
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===CRYSTAL STRUCTURE ANALYSIS OF NORWALK VIRUS CAPSID===
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==Overview==
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Norwalk virus, a noncultivatable human calicivirus, is the major cause of epidemic gastroenteritis in humans. The first x-ray structure of a calicivirus capsid, which consists of 180 copies of a single protein, has been determined by phase extension from a low-resolution electron microscopy structure. The capsid protein has a protruding (P) domain connected by a flexible hinge to a shell (S) domain that has a classical eight-stranded beta-sandwich motif. The structure of the P domain is unlike that of any other viral protein with a subdomain exhibiting a fold similar to that of the second domain in the eukaryotic translation elongation factor-Tu. This subdomain, located at the exterior of the capsid, has the largest sequence variation among Norwalk-like human caliciviruses and is likely to contain the determinants of strain specificity and cell binding.
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(as it appears on PubMed at http://www.pubmed.gov), where 10514371 is the PubMed ID number.
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==About this Structure==
==About this Structure==
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[[Category: Icosahedral virus]]
[[Category: Icosahedral virus]]
[[Category: T=3 icosahedral capsid]]
[[Category: T=3 icosahedral capsid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:00:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 12:12:30 2008''

Revision as of 09:12, 1 July 2008

Image:1ihm.png

Template:STRUCTURE 1ihm

CRYSTAL STRUCTURE ANALYSIS OF NORWALK VIRUS CAPSID

Template:ABSTRACT PUBMED 10514371

About this Structure

1IHM is a Single protein structure of sequence from Norwalk virus. Full crystallographic information is available from OCA.

Reference

X-ray crystallographic structure of the Norwalk virus capsid., Prasad BV, Hardy ME, Dokland T, Bella J, Rossmann MG, Estes MK, Science. 1999 Oct 8;286(5438):287-90. PMID:10514371

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