1ii7

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[[Image:1ii7.gif|left|200px]]
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{{STRUCTURE_1ii7| PDB=1ii7 | SCENE= }}
{{STRUCTURE_1ii7| PDB=1ii7 | SCENE= }}
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'''Crystal structure of P. furiosus Mre11 with manganese and dAMP'''
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===Crystal structure of P. furiosus Mre11 with manganese and dAMP===
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==Overview==
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To clarify functions of the Mre11/Rad50 (MR) complex in DNA double-strand break repair, we report Pyrococcus furiosus Mre11 crystal structures, revealing a protein phosphatase-like, dimanganese binding domain capped by a unique domain controlling active site access. These structures unify Mre11's multiple nuclease activities in a single endo/exonuclease mechanism and reveal eukaryotic macromolecular interaction sites by mapping human and yeast Mre11 mutations. Furthermore, the structure of the P. furiosus Rad50 ABC-ATPase with its adjacent coiled-coil defines a compact Mre11/Rad50-ATPase complex and suggests that Rad50-ATP-driven conformational switching directly controls the Mre11 exonuclease. Electron microscopy, small angle X-ray scattering, and ultracentrifugation data of human and P. furiosus MR reveal a dual functional complex consisting of a (Mre11)2/(Rad50)2 heterotetrameric DNA processing head and a double coiled-coil linker.
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(as it appears on PubMed at http://www.pubmed.gov), where 11371344 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11371344}}
==About this Structure==
==About this Structure==
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[[Category: Mre11]]
[[Category: Mre11]]
[[Category: Rad50]]
[[Category: Rad50]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:01:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 12:15:08 2008''

Revision as of 09:15, 1 July 2008

Image:1ii7.png

Template:STRUCTURE 1ii7

Crystal structure of P. furiosus Mre11 with manganese and dAMP

Template:ABSTRACT PUBMED 11371344

About this Structure

1II7 is a Single protein structure of sequence from Pyrococcus furiosus. Full crystallographic information is available from OCA.

Reference

Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase., Hopfner KP, Karcher A, Craig L, Woo TT, Carney JP, Tainer JA, Cell. 2001 May 18;105(4):473-85. PMID:11371344

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