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1iij

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[[Image:1iij.jpg|left|200px]]
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{{Seed}}
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[[Image:1iij.png|left|200px]]
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{{STRUCTURE_1iij| PDB=1iij | SCENE= }}
{{STRUCTURE_1iij| PDB=1iij | SCENE= }}
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'''SOLUTION STRUCTURE OF THE NEU/ERBB-2 MEMBRANE SPANNING SEGMENT'''
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===SOLUTION STRUCTURE OF THE NEU/ERBB-2 MEMBRANE SPANNING SEGMENT===
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==Overview==
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The 35-residue peptide corresponding to the very hydrophobic transmembrane region of the tyrosine kinase receptor neu, Neu(TM35), has been synthesized. The peptide can be solubilized in millimolar concentrations in TFE or incorporated into an SDS-water micellar solution or into well-hydrated DMPC/DCPC bicelles. In all these media, circular dichroism demonstrated that the peptide adopts a helical structure for about 80% of its amino acids. The peptide is monomeric below 2 mM in TFE, as also determined by variable concentration experiments. The three-dimensional solution structure in TFE has been obtained by homonuclear proton NMR and shows a well-defined alpha-helix from residues 4 to 21, then a pi-bulge from Ile(22) to Gly(28), and a final short alpha-helix from positions 29 to 32. This experimental finding is in agreement with structures predicted recently by molecular dynamics calculations in a vacuum [Sajot, N., and Genest, M. (2000) Eur. Biophys. J. 28, 648-662]. The biological implications of a possible retention of this structure in a membrane environment are finally discussed.
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The line below this paragraph, {{ABSTRACT_PUBMED_11371217}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11371217 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11371217}}
==About this Structure==
==About this Structure==
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1IIJ is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIJ OCA].
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1IIJ is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIJ OCA].
==Reference==
==Reference==
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[[Category: Goetz, M.]]
[[Category: Goetz, M.]]
[[Category: Alpha-helix-pi-bulge-alpha-helix]]
[[Category: Alpha-helix-pi-bulge-alpha-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:02:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 12:16:24 2008''

Revision as of 09:16, 1 July 2008

Image:1iij.png

Template:STRUCTURE 1iij

SOLUTION STRUCTURE OF THE NEU/ERBB-2 MEMBRANE SPANNING SEGMENT

Template:ABSTRACT PUBMED 11371217

About this Structure

1IIJ is a Single protein structure. Full experimental information is available from OCA.

Reference

Evidence for an alpha-helix --> pi-bulge helicity modulation for the neu/erbB-2 membrane-spanning segment. A 1H NMR and circular dichroism study., Goetz M, Carlotti C, Bontems F, Dufourc EJ, Biochemistry. 2001 May 29;40(21):6534-40. PMID:11371217

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