1ijr

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{{STRUCTURE_1ijr| PDB=1ijr | SCENE= }}
{{STRUCTURE_1ijr| PDB=1ijr | SCENE= }}
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'''Crystal structure of LCK SH2 complexed with nonpeptide phosphotyrosine mimetic'''
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===Crystal structure of LCK SH2 complexed with nonpeptide phosphotyrosine mimetic===
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==Overview==
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The novel phosphotyrosine (pTyr) mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp) has been designed and incorporated into a series of nonpeptide inhibitors of the SH2 domain of pp60(c-Src) (Src) tyrosine kinase. A 2.2 A X-ray crystal structure of 1a bound to a mutant form of Lck SH2 domain provides insight regarding the structure-activity relationships and supports the design concept of this new pTyr mimetic.
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{{ABSTRACT_PUBMED_11527723}}
==About this Structure==
==About this Structure==
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[[Category: Yang, M H.]]
[[Category: Yang, M H.]]
[[Category: Tyrosine-protein kinase]]
[[Category: Tyrosine-protein kinase]]
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Revision as of 09:22, 1 July 2008

Image:1ijr.png

Template:STRUCTURE 1ijr

Crystal structure of LCK SH2 complexed with nonpeptide phosphotyrosine mimetic

Template:ABSTRACT PUBMED 11527723

About this Structure

1IJR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain., Kawahata N, Yang MG, Luke GP, Shakespeare WC, Sundaramoorthi R, Wang Y, Johnson D, Merry T, Violette S, Guan W, Bartlett C, Smith J, Hatada M, Lu X, Dalgarno DC, Eyermann CJ, Bohacek RS, Sawyer TK, Bioorg Med Chem Lett. 2001 Sep 3;11(17):2319-23. PMID:11527723

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