1ik1

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[[Image:1ik1.gif|left|200px]]
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{{Seed}}
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[[Image:1ik1.png|left|200px]]
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{{STRUCTURE_1ik1| PDB=1ik1 | SCENE= }}
{{STRUCTURE_1ik1| PDB=1ik1 | SCENE= }}
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'''Solution Structure of an RNA Hairpin from HRV-14'''
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===Solution Structure of an RNA Hairpin from HRV-14===
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==Overview==
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The 5' noncoding region of the picornaviral genome begins with a cloverleaf which is required for viral replication, due at least in part to an interaction with the viral RNA polymerase as part of a fusion with the predominant viral protease. The necessary region of the cloverleaf has previously been narrowed to a highly conserved stem-loop. The solution structure of a 14-nucleotide RNA hairpin, which is part of the conserved stem-loop from human rhinovirus isotype 14, is presented here. The secondary structure of the hairpin is identical to predictions: a five base pair stem is bounded by a triloop with sequence UAU. However, the fold of the triloop is novel, with stacking of the second loop base onto the closing base pair of the stem, and deviations from A form geometry are introduced into the stem regions bordering the triloop, particularly on the 3' side. These deviations and the associated triloop structure could help to explain the distinct sequence conservation and mutational analysis data observed for the stem region of the hairpin, as compared to a second sequentially similar stem in the intact stem-loop.
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The line below this paragraph, {{ABSTRACT_PUBMED_11434774}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11434774 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11434774}}
==About this Structure==
==About this Structure==
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1IK1 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IK1 OCA].
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1IK1 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IK1 OCA].
==Reference==
==Reference==
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[[Category: A form helix]]
[[Category: A form helix]]
[[Category: Triloop]]
[[Category: Triloop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:05:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:18:37 2008''

Revision as of 10:18, 1 July 2008

Image:1ik1.png

Template:STRUCTURE 1ik1

Solution Structure of an RNA Hairpin from HRV-14

Template:ABSTRACT PUBMED 11434774

About this Structure

1IK1 is a Single protein structure. Full experimental information is available from OCA.

Reference

Structure of an RNA hairpin from HRV-14., Huang H, Alexandrov A, Chen X, Barnes TW 3rd, Zhang H, Dutta K, Pascal SM, Biochemistry. 2001 Jul 10;40(27):8055-64. PMID:11434774

Page seeded by OCA on Tue Jul 1 13:18:37 2008

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