1ik3

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[[Image:1ik3.jpg|left|200px]]
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{{Seed}}
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[[Image:1ik3.png|left|200px]]
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{{STRUCTURE_1ik3| PDB=1ik3 | SCENE= }}
{{STRUCTURE_1ik3| PDB=1ik3 | SCENE= }}
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'''LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 13(S)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC ACID'''
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===LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 13(S)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC ACID===
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==Overview==
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Polyunsaturated fatty acid metabolism is governed primarily by two enzymes, prostaglandin H synthase and lipoxygenase. The crystal structure of the metastable product-oxidized purple form of soybean lipoxygenase-3 was determined at 2.0 A resolution. The data reveal that the chromophore corresponds to an iron-peroxide complex, a potential intermediate in the catalyzed reaction. A significant alteration of the iron site accompanies the formation of the complex. The structure, the first for a fatty acid-lipoxygenase complex, also reveals an unexpected mode of binding, and identifies amino acid residues that may play significant roles in catalysis, regio- and stereoselectivity.
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The line below this paragraph, {{ABSTRACT_PUBMED_11686682}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11686682 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11686682}}
==About this Structure==
==About this Structure==
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[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Purple lipoxygenase]]
[[Category: Purple lipoxygenase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:05:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:20:39 2008''

Revision as of 10:20, 1 July 2008

Image:1ik3.png

Template:STRUCTURE 1ik3

LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 13(S)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC ACID

Template:ABSTRACT PUBMED 11686682

About this Structure

1IK3 is a Single protein structure of sequence from Glycine max. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of a purple lipoxygenase., Skrzypczak-Jankun E, Bross RA, Carroll RT, Dunham WR, Funk MO Jr, J Am Chem Soc. 2001 Nov 7;123(44):10814-20. PMID:11686682

Page seeded by OCA on Tue Jul 1 13:20:39 2008

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