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1ikn

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[[Image:1ikn.gif|left|200px]]
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{{STRUCTURE_1ikn| PDB=1ikn | SCENE= }}
{{STRUCTURE_1ikn| PDB=1ikn | SCENE= }}
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'''IKAPPABALPHA/NF-KAPPAB COMPLEX'''
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===IKAPPABALPHA/NF-KAPPAB COMPLEX===
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==Overview==
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IkappaBalpha regulates the transcription factor NF-kappaB through the formation of stable IkappaBalpha/NF-kappaB complexes. Prior to induction, IkappaBalpha retains NF-kappaB in the cytoplasm until the NF-kappaB activation signal is received. After activation, NF-kappaB is removed from gene promoters through association with nuclear IkappaBalpha, restoring the preinduction state. The 2.3 A crystal structure of IkappaBalpha in complex with the NF-kappaB p50/p65 heterodimer reveals mechanisms of these inhibitory activities. The presence of IkappaBalpha allows large en bloc movement of the NF-kappaB p65 subunit amino-terminal domain. This conformational change induces allosteric inhibition of NF-kappaB DNA binding. Amino acid residues immediately preceding the nuclear localization signals of both NF-kappaB p50 and p65 subunits are tethered to the IkappaBalpha amino-terminal ankyrin repeats, impeding NF-kappaB from nuclear import machinery recognition.
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The line below this paragraph, {{ABSTRACT_PUBMED_9865694}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9865694 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9865694}}
==About this Structure==
==About this Structure==
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[[Category: Ikb/nfkb complex]]
[[Category: Ikb/nfkb complex]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:06:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:24:12 2008''

Revision as of 10:24, 1 July 2008

Image:1ikn.png

Template:STRUCTURE 1ikn

IKAPPABALPHA/NF-KAPPAB COMPLEX

Template:ABSTRACT PUBMED 9865694

About this Structure

1IKN is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation., Huxford T, Huang DB, Malek S, Ghosh G, Cell. 1998 Dec 11;95(6):759-70. PMID:9865694

Page seeded by OCA on Tue Jul 1 13:24:12 2008

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