This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1iku

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1iku.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1iku.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1iku| PDB=1iku | SCENE= }}
{{STRUCTURE_1iku| PDB=1iku | SCENE= }}
-
'''MYRISTOYLATED RECOVERIN IN THE CALCIUM-FREE STATE, NMR, 22 STRUCTURES'''
+
===MYRISTOYLATED RECOVERIN IN THE CALCIUM-FREE STATE, NMR, 22 STRUCTURES===
-
==Overview==
+
<!--
-
Recoverin, a retinal calcium-binding protein of relative molecular mass (M(r)) 23K, participates in the recovery phase of visual excitation and in adaptation to background light. The Ca(2+)-bound form of recoverin prolongs the photoresponse, probably by blocking phosphorylation of photoexcited rhodopsin. Retinal recoverin contains a covalently attached myristoyl group or related acyl group at its amino terminus and two Ca(2+)-binding sites. Ca2+ binding to myristoylated, but not unmyristoylated, recoverin induces its translocation to bilayer membranes, indicating that the myristoyl group is essential to the read-out of calcium signals (calcium-myristoyl switch). Here we present the solution structure of Ca(2+)-free, myristoylated recombinant recoverin obtained by heteronuclear multidimensional NMR spectroscopy. The myristoyl group is sequestered in a deep hydrophobic pocket formed by many aromatic and other hydrophobic residues from five flanking helices.
+
The line below this paragraph, {{ABSTRACT_PUBMED_7630423}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 7630423 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_7630423}}
==About this Structure==
==About this Structure==
-
1IKU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IKU OCA].
+
1IKU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IKU OCA].
==Reference==
==Reference==
Line 29: Line 33:
[[Category: Calcium-myristoyl switch]]
[[Category: Calcium-myristoyl switch]]
[[Category: Calcuim-binding protein]]
[[Category: Calcuim-binding protein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:06:37 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:25:15 2008''

Revision as of 10:25, 1 July 2008

Image:1iku.png

Template:STRUCTURE 1iku

MYRISTOYLATED RECOVERIN IN THE CALCIUM-FREE STATE, NMR, 22 STRUCTURES

Template:ABSTRACT PUBMED 7630423

About this Structure

1IKU is a Single protein structure of sequence from Bos taurus. Full experimental information is available from OCA.

Reference

Sequestration of the membrane-targeting myristoyl group of recoverin in the calcium-free state., Tanaka T, Ames JB, Harvey TS, Stryer L, Ikura M, Nature. 1995 Aug 3;376(6539):444-7. PMID:7630423

Page seeded by OCA on Tue Jul 1 13:25:15 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1iku"
Personal tools