1il5

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{{STRUCTURE_1il5| PDB=1il5 | SCENE= }}
{{STRUCTURE_1il5| PDB=1il5 | SCENE= }}
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'''STRUCTURE OF RICIN A CHAIN BOUND WITH INHIBITOR 2,5-DIAMINO-4,6-DIHYDROXYPYRIMIDINE (DDP)'''
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===STRUCTURE OF RICIN A CHAIN BOUND WITH INHIBITOR 2,5-DIAMINO-4,6-DIHYDROXYPYRIMIDINE (DDP)===
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==Overview==
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Ribosome inhibiting proteins, RIPs, are a widespread family of toxic enzymes. Ricin is a plant toxin used as a poison and biological warfare agent; shiga toxin is a homologue expressed by pathogenic strains of E. coli. There is interest in creating effective antidote inhibitors to this class of enzymes. RIPs act by binding and hydrolyzing a specific adenine base from rRNA. Previous virtual screens revealed that pterins could bind in the specificity pocket of ricin and inhibit the enzyme. In this paper we explore a range of compounds that could serve as better platforms for inhibitor design. This establishes the importance of key hydrogen bond donors and acceptors for active-site complementarity. 8-Methyl-9-oxoguanine is a soluble compound that has the best inhibitory properties of any platform tested. The X-ray structure of this complex revealed that the inhibitor binds in an unexpected way that provides insight for future design. Several inhibitors of ricin were also shown to be inhibitors of shiga toxin, suggesting this program has the potential to develop effective antidotes to an important form of food poisoning.
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(as it appears on PubMed at http://www.pubmed.gov), where 11754581 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11754581}}
==About this Structure==
==About this Structure==
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[[Category: Structure-based design]]
[[Category: Structure-based design]]
[[Category: Toxin-inhibitor complex]]
[[Category: Toxin-inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:07:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:26:29 2008''

Revision as of 10:26, 1 July 2008

Image:1il5.png

Template:STRUCTURE 1il5

STRUCTURE OF RICIN A CHAIN BOUND WITH INHIBITOR 2,5-DIAMINO-4,6-DIHYDROXYPYRIMIDINE (DDP)

Template:ABSTRACT PUBMED 11754581

About this Structure

1IL5 is a Single protein structure of sequence from Ricinus communis. Full crystallographic information is available from OCA.

Reference

Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition., Miller DJ, Ravikumar K, Shen H, Suh JK, Kerwin SM, Robertus JD, J Med Chem. 2002 Jan 3;45(1):90-8. PMID:11754581

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