1ily

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{{STRUCTURE_1ily| PDB=1ily | SCENE= }}
{{STRUCTURE_1ily| PDB=1ily | SCENE= }}
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'''Solution Structure of Ribosomal Protein L18 of Thermus thermophilus'''
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===Solution Structure of Ribosomal Protein L18 of Thermus thermophilus===
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==Overview==
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We have determined the solution structure of ribosomal protein L18 from Thermus thermophilus. L18 is a 12.5 kDa protein of the large subunit of the ribosome and binds to both 5 S and 23 S rRNA. In the uncomplexed state L18 folds to a mixed alpha/beta globular structure with a long disordered N-terminal region. We compared our high-resolution structure with RNA-complexed L18 from Haloarcula marismortui and T. thermophilus to examine RNA-induced as well as species-dependent structural differences. We also identified T. thermophilus S11 as a structural homologue and found that the structures of the RNA-recognition sites are conserved. Important features, for instance a bulge in the RNA-contacting beta-sheet, are conserved in both proteins. We suggest that the L18 fold recognizes a specific RNA motif and that the resulting RNA-protein-recognition module is tolerant to variations in sequence.
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{{ABSTRACT_PUBMED_11964156}}
==About this Structure==
==About this Structure==
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1ILY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ILY OCA].
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1ILY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ILY OCA].
==Reference==
==Reference==
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[[Category: Woestenenk, E A.]]
[[Category: Woestenenk, E A.]]
[[Category: Mixed alpha/beta]]
[[Category: Mixed alpha/beta]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:29:43 2008''

Revision as of 10:29, 1 July 2008

Image:1ily.png

Template:STRUCTURE 1ily

Solution Structure of Ribosomal Protein L18 of Thermus thermophilus

Template:ABSTRACT PUBMED 11964156

About this Structure

1ILY is a Single protein structure of sequence from Thermus thermophilus. Full experimental information is available from OCA.

Reference

The solution structure of ribosomal protein L18 from Thermus thermophilus reveals a conserved RNA-binding fold., Woestenenk EA, Gongadze GM, Shcherbakov DV, Rak AV, Garber MB, Hard T, Berglund H, Biochem J. 2002 May 1;363(Pt 3):553-61. PMID:11964156

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