1im2

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{{STRUCTURE_1im2| PDB=1im2 | SCENE= }}
{{STRUCTURE_1im2| PDB=1im2 | SCENE= }}
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'''HslU, Haemophilus Influenzae, Selenomethionine Variant'''
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===HslU, Haemophilus Influenzae, Selenomethionine Variant===
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==Overview==
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The structure of the Haemophilus influenzae HslU protein, a molecular chaperone of the Clp/Hsp100 family, has been solved to 2.3 A by molecular replacement using a model of the homologous Escherichia coli protein. The crystals in which the structure was solved have an unusual twinning, or one-dimensional disorder, in which each successive crystal-packing layer is displaced laterally relative to the one below it. A model for the twinning and an algorithm for detwinning the data are described. It is known from other work that when the HslU hexamer binds its cognate protease HslV, the carboxy-terminal helices of HslU protomers distend and bind between HslV subunits. Comparison of HslU alone with its structure in the HslUV complex reveals several conserved amino-acid residues whose side-chain interactions differ between the two structures, suggesting that they may be part of a conformational switch that facilitates the release of the HslU carboxy-terminal helices when HslV binds.
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(as it appears on PubMed at http://www.pubmed.gov), where 11468391 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11468391}}
==About this Structure==
==About this Structure==
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[[Category: Aaa family]]
[[Category: Aaa family]]
[[Category: Chaperone]]
[[Category: Chaperone]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:30:33 2008''

Revision as of 10:30, 1 July 2008

Image:1im2.png

Template:STRUCTURE 1im2

HslU, Haemophilus Influenzae, Selenomethionine Variant

Template:ABSTRACT PUBMED 11468391

About this Structure

1IM2 is a Single protein structure of sequence from Haemophilus influenzae. Full crystallographic information is available from OCA.

Reference

Structure of Haemophilus influenzae HslU protein in crystals with one-dimensional disorder twinning., Trame CB, McKay DB, Acta Crystallogr D Biol Crystallogr. 2001 Aug;57(Pt 8):1079-90. Epub 2001, Jul 23. PMID:11468391

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