1io0

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{{STRUCTURE_1io0| PDB=1io0 | SCENE= }}
{{STRUCTURE_1io0| PDB=1io0 | SCENE= }}
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'''CRYSTAL STRUCTURE OF TROPOMODULIN C-TERMINAL HALF'''
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===CRYSTAL STRUCTURE OF TROPOMODULIN C-TERMINAL HALF===
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==Overview==
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Tropomodulin is the unique pointed-end capping protein of the actin-tropomyosin filament. By blocking elongation and depolymerization, tropomodulin regulates the architecture and the dynamics of the filament. Here we report the crystal structure at 1.45-A resolution of the C-terminal half of tropomodulin (C20), the actin-binding moiety of tropomodulin. C20 is a leucine-rich repeat domain, and this is the first actin-associated protein with a leucine-rich repeat. Binding assays suggested that C20 also interacts with the N-terminal fragment, M1-M2-M3, of nebulin. Based on the crystal structure, we propose a model for C20 docking to the actin subunit at the pointed end. Although speculative, the model is consistent with the idea that a tropomodulin molecule competes with an actin subunit for a pointed end. The model also suggests that interactions with tropomyosin, actin, and nebulin are all possible sources of influences on the dynamic properties of pointed-end capping by tropomodulin.
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(as it appears on PubMed at http://www.pubmed.gov), where 12414704 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12414704}}
==About this Structure==
==About this Structure==
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[[Category: Lrr protein]]
[[Category: Lrr protein]]
[[Category: Right-handed super-helix]]
[[Category: Right-handed super-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:12:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:38:44 2008''

Revision as of 10:38, 1 July 2008

Image:1io0.png

Template:STRUCTURE 1io0

CRYSTAL STRUCTURE OF TROPOMODULIN C-TERMINAL HALF

Template:ABSTRACT PUBMED 12414704

About this Structure

1IO0 is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the C-terminal half of tropomodulin and structural basis of actin filament pointed-end capping., Krieger I, Kostyukova A, Yamashita A, Nitanai Y, Maeda Y, Biophys J. 2002 Nov;83(5):2716-25. PMID:12414704

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