1ioj

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[[Image:1ioj.gif|left|200px]]
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{{STRUCTURE_1ioj| PDB=1ioj | SCENE= }}
{{STRUCTURE_1ioj| PDB=1ioj | SCENE= }}
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'''HUMAN APOLIPOPROTEIN C-I, NMR, 18 STRUCTURES'''
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===HUMAN APOLIPOPROTEIN C-I, NMR, 18 STRUCTURES===
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==Overview==
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Apolipoprotein (apo) C-I is a 57-residue exchangeable plasma protein distributed mainly in high and very low density lipoprotein. In this report we present the nuclear magnetic resonance spectra of native apoC-I and synthetic apoC-I, containing selected 15N-labelled amino acids, in the presence of sodium dodecyl sulfate. The proton resonances of apoC-I are assigned and the secondary structure is estimated from the difference of measured alpha-proton chemical shifts to random coil values and the observed NOE interactions. According to these data apoC-I forms two helices, Val-4-Lys-30 and Leu-34-Lys-52, linked by an unstructured region Gln-31-Glu-33. The N-terminal segments of each helix, Val-4-Gly-15 and Leu-34-Met-38, appear to be more flexible than the helical core regions Asn-16-Lys-30 and Arg-39-Lys-52.
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{{ABSTRACT_PUBMED_9923695}}
==About this Structure==
==About this Structure==
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1IOJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IOJ OCA].
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1IOJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IOJ OCA].
==Reference==
==Reference==
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[[Category: Lcat activation]]
[[Category: Lcat activation]]
[[Category: Lipid association]]
[[Category: Lipid association]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:13:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:42:05 2008''

Revision as of 10:42, 1 July 2008

Image:1ioj.png

Template:STRUCTURE 1ioj

HUMAN APOLIPOPROTEIN C-I, NMR, 18 STRUCTURES

Template:ABSTRACT PUBMED 9923695

About this Structure

1IOJ is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Sequence-specific 1H NMR resonance assignments and secondary structure of human apolipoprotein C-I in the presence of sodium dodecyl sulfate., Rozek A, Sparrow JT, Weisgraber KH, Cushley RJ, Biochem Cell Biol. 1998;76(2-3):267-75. PMID:9923695

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