1ip9

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{{STRUCTURE_1ip9| PDB=1ip9 | SCENE= }}
{{STRUCTURE_1ip9| PDB=1ip9 | SCENE= }}
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'''SOLUTION STRUCTURE OF THE PB1 DOMAIN OF BEM1P'''
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===SOLUTION STRUCTURE OF THE PB1 DOMAIN OF BEM1P===
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==Overview==
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PB1 domains are novel protein modules capable of binding to target proteins that contain PC motifs. We report here the NMR structure and ligand-binding site of the PB1 domain of the cell polarity establishment protein, Bem1p. In addition, we identify the topology of the PC motif-containing region of Cdc24p by NMR, another cell polarity establishment protein that interacts with Bem1p. The PC motif-containing region is a structural domain offering a scaffold to the PC motif. The chemical shift perturbation experiment and the mutagenesis study show that the PC motif is a major structural element that binds to the PB1 domain. A structural database search reveals close similarity between the Bem1p PB1 domain and the c-Raf1 Ras-binding domain. However, these domains are functionally distinct from each other.
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(as it appears on PubMed at http://www.pubmed.gov), where 11483498 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11483498}}
==About this Structure==
==About this Structure==
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1IP9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IP9 OCA].
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1IP9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IP9 OCA].
==Reference==
==Reference==
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[[Category: Terasawa, H.]]
[[Category: Terasawa, H.]]
[[Category: Ubiquitin alpha/beta roll]]
[[Category: Ubiquitin alpha/beta roll]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:14:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:44:26 2008''

Revision as of 10:44, 1 July 2008

Image:1ip9.png

Template:STRUCTURE 1ip9

SOLUTION STRUCTURE OF THE PB1 DOMAIN OF BEM1P

Template:ABSTRACT PUBMED 11483498

About this Structure

1IP9 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

Structure and ligand recognition of the PB1 domain: a novel protein module binding to the PC motif., Terasawa H, Noda Y, Ito T, Hatanaka H, Ichikawa S, Ogura K, Sumimoto H, Inagaki F, EMBO J. 2001 Aug 1;20(15):3947-56. PMID:11483498

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