1irk

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{{STRUCTURE_1irk| PDB=1irk | SCENE= }}
{{STRUCTURE_1irk| PDB=1irk | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HUMAN INSULIN RECEPTOR'''
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===CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HUMAN INSULIN RECEPTOR===
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==Overview==
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The X-ray crystal structure of the tyrosine kinase domain of the human insulin receptor has been determined by multiwavelength anomalous diffraction phasing and refined to 2.1 A resolution. The structure reveals the determinants of substrate preference for tyrosine rather than serine or threonine and a novel autoinhibition mechanism whereby one of the tyrosines that is autophosphorylated in response to insulin, Tyr 1,162, is bound in the active site.
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The line below this paragraph, {{ABSTRACT_PUBMED_7997262}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7997262 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7997262}}
==About this Structure==
==About this Structure==
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[[Category: Hubbard, S R.]]
[[Category: Hubbard, S R.]]
[[Category: Wei, L.]]
[[Category: Wei, L.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:19:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:52:39 2008''

Revision as of 10:52, 1 July 2008

Template:STRUCTURE 1irk

CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HUMAN INSULIN RECEPTOR

Template:ABSTRACT PUBMED 7997262

About this Structure

1IRK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the tyrosine kinase domain of the human insulin receptor., Hubbard SR, Wei L, Ellis L, Hendrickson WA, Nature. 1994 Dec 22-29;372(6508):746-54. PMID:7997262

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