1is4

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{{STRUCTURE_1is4| PDB=1is4 | SCENE= }}
{{STRUCTURE_1is4| PDB=1is4 | SCENE= }}
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'''LACTOSE-LIGANDED CONGERIN II'''
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===LACTOSE-LIGANDED CONGERIN II===
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==Overview==
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The crystal structure of congerin II, a galectin family lectin from conger eel, was determined at 1.45A resolution. The previously determined structure of its isoform, congerin I, had revealed a fold evolution via strand swap; however, the structure of congerin II described here resembles other prototype galectins. A comparison of the two congerin genes with that of several other galectins suggests acceralated evolution of both congerin genes following gene duplication. The presence of a Mes (2-[N-morpholino]ethanesulfonic acid) molecule near the carbohydrate-binding site in the crystal structure points to the possibility of an additional binding site in congerin II. The binding site consists of a group of residues that had been replaced following gene duplication suggesting that the binding site was built under selective pressure. Congerin II may be a protein specialized for biological defense with an affinity for target carbohydrates on parasites' cell surface.
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{{ABSTRACT_PUBMED_12206768}}
==About this Structure==
==About this Structure==
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[[Category: Beta sandwich]]
[[Category: Beta sandwich]]
[[Category: Complex with lactose]]
[[Category: Complex with lactose]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:20:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:54:27 2008''

Revision as of 10:54, 1 July 2008

Image:1is4.png

Template:STRUCTURE 1is4

LACTOSE-LIGANDED CONGERIN II

Template:ABSTRACT PUBMED 12206768

About this Structure

1IS4 is a Single protein structure of sequence from Conger myriaster. Full crystallographic information is available from OCA.

Reference

Crystal structure of a conger eel galectin (congerin II) at 1.45A resolution: implication for the accelerated evolution of a new ligand-binding site following gene duplication., Shirai T, Matsui Y, Shionyu-Mitsuyama C, Yamane T, Kamiya H, Ishii C, Ogawa T, Muramoto K, J Mol Biol. 2002 Aug 30;321(5):879-89. PMID:12206768

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