1iu9

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{{STRUCTURE_1iu9| PDB=1iu9 | SCENE= }}
{{STRUCTURE_1iu9| PDB=1iu9 | SCENE= }}
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'''Crystal structure of the C-terminal domain of aspartate racemase from Pyrococcus horikoshii OT3'''
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===Crystal structure of the C-terminal domain of aspartate racemase from Pyrococcus horikoshii OT3===
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==Overview==
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The X-ray crystal structure has revealed two similar alpha/beta domains of aspartate racemase (AspR) from Pyrococcus horikoshii OT3, and identified a pseudo mirror-symmetric distribution of the residues around its active site [Liu et al. (2002) J. Mol. Biol. 319, 479-489]. Structural homology and functional similarity between the two domains suggested that this enzyme evolved from an ancestral domain by gene duplication and gene fusion. We have expressed solely the C-terminal domain of this AspR and determined its three-dimensional structure by X-ray crystallography. The high structural stability of this domain supports the existence of the ancestral domain. In comparison with other amino acid racemases (AARs), we suggest that gene duplication and gene fusion are conventional ways in the evolution of pyridoxal 5'-phosphate-independent AARs.
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(as it appears on PubMed at http://www.pubmed.gov), where 12297289 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12297289}}
==About this Structure==
==About this Structure==
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[[Category: C-terminal domain]]
[[Category: C-terminal domain]]
[[Category: Crystal structure]]
[[Category: Crystal structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:25:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:00:45 2008''

Revision as of 11:00, 1 July 2008

Image:1iu9.png

Template:STRUCTURE 1iu9

Crystal structure of the C-terminal domain of aspartate racemase from Pyrococcus horikoshii OT3

Template:ABSTRACT PUBMED 12297289

About this Structure

1IU9 is a Single protein structure of sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.

Reference

Structural insight into gene duplication, gene fusion and domain swapping in the evolution of PLP-independent amino acid racemases., Liu L, Iwata K, Yohda M, Miki K, FEBS Lett. 2002 Sep 25;528(1-3):114-8. PMID:12297289

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