1iuc

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[[Image:1iuc.jpg|left|200px]]
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{{STRUCTURE_1iuc| PDB=1iuc | SCENE= }}
{{STRUCTURE_1iuc| PDB=1iuc | SCENE= }}
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'''Fucose-specific lectin from Aleuria aurantia with three ligands'''
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===Fucose-specific lectin from Aleuria aurantia with three ligands===
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==Overview==
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Aleuria aurantia possesses a fucose-specific lectin (AAL) that is widely used as a specific probe for fucose. Fucosylated sugars often play pivotal roles in many cellular processes. We have determined the crystal structure of AAL at 2.24 A resolution in complex with only three fucose molecules in its five sugar binding sites of a six-fold beta-propeller structure. Very recently, the structure of AAL has been independently determined, showing that all the five binding sites were occupied by fucose molecules [Wimmerova, M., et al. (2003) J. Biol. Chem. 278, 27059-27067]. Stabilization of the arginine conformation bound to fucose molecules plays an essential role in generating the difference in the affinity in the five binding sites. Binding models with a couple of saccharides based on biochemical assays suggest that hydrophobic contacts also play important roles in AAL recognizing its ligand.
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(as it appears on PubMed at http://www.pubmed.gov), where 14503859 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14503859}}
==About this Structure==
==About this Structure==
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[[Category: Rsgi]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:00:47 2008''

Revision as of 11:00, 1 July 2008

Image:1iuc.png

Template:STRUCTURE 1iuc

Fucose-specific lectin from Aleuria aurantia with three ligands

Template:ABSTRACT PUBMED 14503859

About this Structure

1IUC is a Single protein structure of sequence from Aleuria aurantia. Full crystallographic information is available from OCA.

Reference

Crystal structure of fucose-specific lectin from Aleuria aurantia binding ligands at three of its five sugar recognition sites., Fujihashi M, Peapus DH, Kamiya N, Nagata Y, Miki K, Biochemistry. 2003 Sep 30;42(38):11093-9. PMID:14503859

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