1ivm

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[[Image:1ivm.gif|left|200px]]
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{{STRUCTURE_1ivm| PDB=1ivm | SCENE= }}
{{STRUCTURE_1ivm| PDB=1ivm | SCENE= }}
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'''Solution structure of mouse lysozyme M'''
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===Solution structure of mouse lysozyme M===
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==Overview==
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The three-dimensional structure of mouse lysozyme M, glycoside hydrolase, with 130 amino acids has been determined by heteronuclear NMR spectroscopy. We found that mouse lysozyme M had four alpha-helices, two 3(10)helices, and a double- and a triple-stranded anti-parallel beta-sheet, and its structure was very similar to that of hen lysozyme in solution and in the crystalline state. The pH activity profile of p-nitrophenyl penta N-acetyl-beta-D-chitopentaoside hydrolysis by mouse lysozyme M was similar to that of hen lysozyme, but the hydrolytic activity of mouse lysozyme M was lower. From analyses of binding affinities of lysozymes to a substrate analogue and internal motions of lysozymes, we suggest that the lower activity of mouse lysozyme M was due to the larger dissociation constant of its enzyme-substrate complex and the restricted internal backbone motions in the molecule.
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The line below this paragraph, {{ABSTRACT_PUBMED_12613666}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12613666 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12613666}}
==About this Structure==
==About this Structure==
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1IVM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IVM OCA].
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1IVM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IVM OCA].
==Reference==
==Reference==
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[[Category: Glycosidase]]
[[Category: Glycosidase]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:28:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:04:40 2008''

Revision as of 11:04, 1 July 2008

Image:1ivm.png

Template:STRUCTURE 1ivm

Solution structure of mouse lysozyme M

Template:ABSTRACT PUBMED 12613666

About this Structure

1IVM is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Solution structure and activity of mouse lysozyme M., Obita T, Ueda T, Imoto T, Cell Mol Life Sci. 2003 Jan;60(1):176-84. PMID:12613666

Page seeded by OCA on Tue Jul 1 14:04:40 2008

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