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1iwc

From Proteopedia

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[[Image:1iwc.jpg|left|200px]]
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{{STRUCTURE_1iwc| PDB=1iwc | SCENE= }}
{{STRUCTURE_1iwc| PDB=1iwc | SCENE= }}
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'''TFE-induded structure of the N-terminal domain of pig gastric H/K-ATPase'''
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===TFE-induded structure of the N-terminal domain of pig gastric H/K-ATPase===
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==Overview==
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It has been well established that phosphorylation is an important reaction for the regulation of protein functions. In the N-terminal domain of the alpha-chain of pig gastric H(+)/K(+)-ATPase, reversible sequential phosphorylation occurs at Tyr 10 and Tyr 7. In this study, we determined the structure of the peptide involving the residues from Gly 2 to Gly 34 of pig gastric H(+)/K(+)-ATPase and investigated the tyrosine phosphorylation-induced conformational change using CD and NMR experiments. The solution structure showed that the N-terminal fragment has a helical conformation, and the peptide adopted two alpha-helices in 50% trifluoroethanol (TFE) solvent, suggesting that the peptide has a high helical propensity under hydrophobic conditions. Furthermore, the CD and NMR data suggested that the structure of the N-terminal fragment becomes more disordered as a result of phosphorylation of Tyr 10. This conformational change induced by the phosphorylation of Tyr 10 might be an advantageous reaction for sequential phosphorylation and may be important for regulating the function of H(+)/K(+)-ATPase.
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(as it appears on PubMed at http://www.pubmed.gov), where 12480547 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12480547}}
==About this Structure==
==About this Structure==
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1IWC is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IWC OCA].
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1IWC is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IWC OCA].
==Reference==
==Reference==
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[[Category: Taniguchi, K.]]
[[Category: Taniguchi, K.]]
[[Category: Tfe-induced structure]]
[[Category: Tfe-induced structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:30:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:07:08 2008''

Revision as of 11:07, 1 July 2008

Image:1iwc.png

Template:STRUCTURE 1iwc

TFE-induded structure of the N-terminal domain of pig gastric H/K-ATPase

Template:ABSTRACT PUBMED 12480547

About this Structure

1IWC is a Single protein structure. Full experimental information is available from OCA.

Reference

Structure determination and conformational change induced by tyrosine phosphorylation of the N-terminal domain of the alpha-chain of pig gastric H+/K+-ATPase., Fujitani N, Kanagawa M, Aizawa T, Ohkubo T, Kaya S, Demura M, Kawano K, Nishimura S, Taniguchi K, Nitta K, Biochem Biophys Res Commun. 2003 Jan 3;300(1):223-9. PMID:12480547

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