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1ixs

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[[Image:1ixs.gif|left|200px]]
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{{STRUCTURE_1ixs| PDB=1ixs | SCENE= }}
{{STRUCTURE_1ixs| PDB=1ixs | SCENE= }}
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'''Structure of RuvB complexed with RuvA domain III'''
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===Structure of RuvB complexed with RuvA domain III===
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==Overview==
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We present the X-ray structure of the RuvA-RuvB complex, which plays a crucial role in ATP-dependent branch migration. Two RuvA tetramers form the symmetric and closed octameric shell, where four RuvA domain IIIs spring out in the two opposite directions to be individually caught by a single RuvB. The binding of domain III deforms the protruding beta hairpin in the N-terminal domain of RuvB and thereby appears to induce a functional and less symmetric RuvB hexameric ring. The model of the RuvA-RuvB junction DNA ternary complex, constructed by fitting the X-ray structure into the averaged electron microscopic images of the RuvA-RuvB junction, appears to be more compatible with the branch migration mode of a fixed RuvA-RuvB interaction than with a rotational interaction mode.
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(as it appears on PubMed at http://www.pubmed.gov), where 12408833 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12408833}}
==About this Structure==
==About this Structure==
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[[Category: Complex with nucleotide]]
[[Category: Complex with nucleotide]]
[[Category: Heterodimeric protein complex]]
[[Category: Heterodimeric protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:33:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:11:26 2008''

Revision as of 11:11, 1 July 2008

Image:1ixs.png

Template:STRUCTURE 1ixs

Structure of RuvB complexed with RuvA domain III

Template:ABSTRACT PUBMED 12408833

About this Structure

1IXS is a Protein complex structure of sequences from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the RuvA-RuvB complex: a structural basis for the Holliday junction migrating motor machinery., Yamada K, Miyata T, Tsuchiya D, Oyama T, Fujiwara Y, Ohnishi T, Iwasaki H, Shinagawa H, Ariyoshi M, Mayanagi K, Morikawa K, Mol Cell. 2002 Sep;10(3):671-81. PMID:12408833

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