1iy2

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{{STRUCTURE_1iy2| PDB=1iy2 | SCENE= }}
{{STRUCTURE_1iy2| PDB=1iy2 | SCENE= }}
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'''Crystal structure of the FtsH ATPase domain from Thermus thermophilus'''
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===Crystal structure of the FtsH ATPase domain from Thermus thermophilus===
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==Overview==
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FtsH is a cytoplasmic membrane-integrated, ATP-dependent metalloprotease, which processively degrades both cytoplasmic and membrane proteins in concert with unfolding. The FtsH protein is divided into the N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. We have determined the crystal structures of the Thermus thermophilus FtsH ATPase domain in the nucleotide-free and AMP-PNP- and ADP-bound states, in addition to the domain with the extra preceding segment. Combined with the mapping of the putative substrate binding region, these structures suggest that FtsH internally forms a hexameric ring structure, in which ATP binding could cause a conformational change to facilitate transport of substrates into the protease domain through the central pore.
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(as it appears on PubMed at http://www.pubmed.gov), where 12377127 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12377127}}
==About this Structure==
==About this Structure==
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[[Category: Yoshida, M.]]
[[Category: Yoshida, M.]]
[[Category: Aaa domain fold]]
[[Category: Aaa domain fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:12:11 2008''

Revision as of 11:12, 1 July 2008

Image:1iy2.png

Template:STRUCTURE 1iy2

Crystal structure of the FtsH ATPase domain from Thermus thermophilus

Template:ABSTRACT PUBMED 12377127

About this Structure

1IY2 is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Hexameric ring structure of the ATPase domain of the membrane-integrated metalloprotease FtsH from Thermus thermophilus HB8., Niwa H, Tsuchiya D, Makyio H, Yoshida M, Morikawa K, Structure. 2002 Oct;10(10):1415-23. PMID:12377127

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