1iyj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1iyj.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1iyj.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1iyj| PDB=1iyj | SCENE= }}
{{STRUCTURE_1iyj| PDB=1iyj | SCENE= }}
-
'''STRUCTURE OF A BRCA2-DSS1 COMPLEX'''
+
===STRUCTURE OF A BRCA2-DSS1 COMPLEX===
-
==Overview==
+
<!--
-
Mutations in the BRCA2 (breast cancer susceptibility gene 2) tumor suppressor lead to chromosomal instability due to defects in the repair of double-strand DNA breaks (DSBs) by homologous recombination, but BRCA2's role in this process has been unclear. Here, we present the 3.1 angstrom crystal structure of a approximately 90-kilodalton BRCA2 domain bound to DSS1, which reveals three oligonucleotide-binding (OB) folds and a helix-turn-helix (HTH) motif. We also (i) demonstrate that this BRCA2 domain binds single-stranded DNA, (ii) present its 3.5 angstrom structure bound to oligo(dT)9, (iii) provide data that implicate the HTH motif in dsDNA binding, and (iv) show that BRCA2 stimulates RAD51-mediated recombination in vitro. These findings establish that BRCA2 functions directly in homologous recombination and provide a structural and biochemical basis for understanding the loss of recombination-mediated DSB repair in BRCA2-associated cancers.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12228710}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12228710 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12228710}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Dna-binding]]
[[Category: Dna-binding]]
[[Category: Tumor suppressor]]
[[Category: Tumor suppressor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:35:09 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:13:30 2008''

Revision as of 11:13, 1 July 2008

Image:1iyj.png

Template:STRUCTURE 1iyj

STRUCTURE OF A BRCA2-DSS1 COMPLEX

Template:ABSTRACT PUBMED 12228710

About this Structure

1IYJ is a Protein complex structure of sequences from Homo sapiens and Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure., Yang H, Jeffrey PD, Miller J, Kinnucan E, Sun Y, Thoma NH, Zheng N, Chen PL, Lee WH, Pavletich NP, Science. 2002 Sep 13;297(5588):1837-48. PMID:12228710

Page seeded by OCA on Tue Jul 1 14:13:30 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1iyj"
Personal tools