1izc

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{{STRUCTURE_1izc| PDB=1izc | SCENE= }}
{{STRUCTURE_1izc| PDB=1izc | SCENE= }}
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'''Crystal Structure Analysis of Macrophomate synthase'''
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===Crystal Structure Analysis of Macrophomate synthase===
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==Overview==
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The Diels-Alder reaction, which forms a six-membered ring from an alkene (dienophile) and a 1,3-diene, is synthetically very useful for construction of cyclic products with high regio- and stereoselectivity under mild conditions. It has been applied to the synthesis of complex pharmaceutical and biologically active compounds. Although evidence on natural Diels-Alderases has been accumulated in the biosynthesis of secondary metabolites, there has been no report on the structural details of the natural Diels-Alderases. The function and catalytic mechanism of the natural Diels-Alderase are of great interest owing to the diversity of molecular skeletons in natural Diels-Alder adducts. Here we present the 1.70 A resolution crystal structure of the natural Diels-Alderase, fungal macrophomate synthase (MPS), in complex with pyruvate. The active site of the enzyme is large and hydrophobic, contributing amino acid residues that can hydrogen-bond to the substrate 2-pyrone. These data provide information on the catalytic mechanism of MPS, and suggest that the reaction proceeds via a large-scale structural reorganization of the product.
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The line below this paragraph, {{ABSTRACT_PUBMED_12634789}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12634789 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12634789}}
==About this Structure==
==About this Structure==
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[[Category: Yao, M.]]
[[Category: Yao, M.]]
[[Category: Tim-barrel]]
[[Category: Tim-barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:37:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:15:51 2008''

Revision as of 11:15, 1 July 2008

Image:1izc.png

Template:STRUCTURE 1izc

Crystal Structure Analysis of Macrophomate synthase

Template:ABSTRACT PUBMED 12634789

About this Structure

1IZC is a Single protein structure of sequence from Macrophoma commelinae. Full crystallographic information is available from OCA.

Reference

Insight into a natural Diels-Alder reaction from the structure of macrophomate synthase., Ose T, Watanabe K, Mie T, Honma M, Watanabe H, Yao M, Oikawa H, Tanaka I, Nature. 2003 Mar 13;422(6928):185-9. PMID:12634789

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