1izy

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{{STRUCTURE_1izy| PDB=1izy | SCENE= }}
{{STRUCTURE_1izy| PDB=1izy | SCENE= }}
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'''Crystal structure of Hsp31'''
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===Crystal structure of Hsp31===
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==Overview==
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Human DJ-1 and Escherichia coli Hsp31 belong to ThiJ/PfpI family, whose members contain a conserved domain. DJ-1 is associated with autosomal recessive early onset parkinsonism and Hsp31 is a molecular chaperone. Structural comparisons between DJ-1, Hsp31, and an Archaea protease, a member of ThiJ/PfpI family, lead to the identification of the chaperone activity of DJ-1 and the proteolytic activity of Hsp31. Moreover, the comparisons provide insights into how the functional diversity is realized in proteins that share an evolutionarily conserved domain. On the basis of the chaperone activity the possible role of DJ-1 in the pathogenesis of Parkinson's disease is discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 12939276 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12939276}}
==About this Structure==
==About this Structure==
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[[Category: Lee, S J.]]
[[Category: Lee, S J.]]
[[Category: Alpha-beta sandwitch]]
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Revision as of 11:17, 1 July 2008

Template:STRUCTURE 1izy

Crystal structure of Hsp31

Template:ABSTRACT PUBMED 12939276

About this Structure

1IZY is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain., Lee SJ, Kim SJ, Kim IK, Ko J, Jeong CS, Kim GH, Park C, Kang SO, Suh PG, Lee HS, Cha SS, J Biol Chem. 2003 Nov 7;278(45):44552-9. Epub 2003 Aug 25. PMID:12939276

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