1j0x

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[[Image:1j0x.gif|left|200px]]
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{{Seed}}
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[[Image:1j0x.png|left|200px]]
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{{STRUCTURE_1j0x| PDB=1j0x | SCENE= }}
{{STRUCTURE_1j0x| PDB=1j0x | SCENE= }}
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'''Crystal structure of the rabbit muscle glyceraldehyde-3-phosphate dehydrogenase (GAPDH)'''
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===Crystal structure of the rabbit muscle glyceraldehyde-3-phosphate dehydrogenase (GAPDH)===
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==Overview==
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The crystal structure of the tetrameric form of D-glyceraldehyde-3-phosphate dehydrogenase (GAPDH) isolated from rabbit muscle was solved at 2.4 A resolution after careful dynamic light-scattering experiments to find a suitable buffer for crystallization trials. The refined model has a crystallographic R factor of 20.3%. Here, the first detailed model of a mammalian GAPDH is presented. The cofactor NAD(+) (nicotinamide adenine dinucleotide) is bound to two subunits of the tetrameric enzyme, which is consistent with the negative cooperativity of NAD(+) binding to this enzyme. The structure of rabbit-muscle GAPDH is of interest because it shares 91% sequence identity with the human enzyme; human GAPDH is a potential target for the development of anti-apoptotic drugs. In addition, differences in the cofactor-binding pocket compared with the homology-model structure of GAPDH from the malaria parasite Plasmodium falciparum could be exploited in order to develop novel selective and potential antimalaria drugs.
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The line below this paragraph, {{ABSTRACT_PUBMED_14646080}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14646080 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14646080}}
==About this Structure==
==About this Structure==
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[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Rossmann fold]]
[[Category: Rossmann fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:40:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:19:46 2008''

Revision as of 11:19, 1 July 2008

Image:1j0x.png

Template:STRUCTURE 1j0x

Crystal structure of the rabbit muscle glyceraldehyde-3-phosphate dehydrogenase (GAPDH)

Template:ABSTRACT PUBMED 14646080

About this Structure

1J0X is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Structure of rabbit-muscle glyceraldehyde-3-phosphate dehydrogenase., Cowan-Jacob SW, Kaufmann M, Anselmo AN, Stark W, Grutter MG, Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2218-27. Epub 2003, Nov 27. PMID:14646080

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