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1j2e

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{{STRUCTURE_1j2e| PDB=1j2e | SCENE= }}
{{STRUCTURE_1j2e| PDB=1j2e | SCENE= }}
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'''Crystal structure of Human Dipeptidyl peptidase IV'''
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===Crystal structure of Human Dipeptidyl peptidase IV===
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==Overview==
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Dipeptidyl peptidase IV (DPPIV) is a serine protease, a member of the prolyl oligopeptidase (POP) family, and has been implicated in several diseases. Therefore, the development of DPPIV selective inhibitors, which are able to control the biological function of DPPIV, is important. We determined the crystal structure of human DPPIV at 2.6A resolution. The molecule consists of a unique eight-bladed beta-propeller domain in the N-terminal region and a serine protease domain in the C-terminal region. Also, the large "cave" structure, which is thought to control the access of the substrate, is found on the side of the beta-propeller fold. Comparison of the overall amino acid sequence between human DPPIV and POP shows low homology (12.9%). In this paper, we report the structure of human DPPIV, especially focusing on a unique eight-bladed beta-propeller domain. We also discuss the way for the access of the substrate to this domain.
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(as it appears on PubMed at http://www.pubmed.gov), where 12646248 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12646248}}
==About this Structure==
==About this Structure==
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[[Category: Prolyl oligopeptidase]]
[[Category: Prolyl oligopeptidase]]
[[Category: Serine protease]]
[[Category: Serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:43:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:24:01 2008''

Revision as of 11:24, 1 July 2008

Image:1j2e.png

Template:STRUCTURE 1j2e

Crystal structure of Human Dipeptidyl peptidase IV

Template:ABSTRACT PUBMED 12646248

About this Structure

1J2E is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure and function of human dipeptidyl peptidase IV, possessing a unique eight-bladed beta-propeller fold., Hiramatsu H, Kyono K, Higashiyama Y, Fukushima C, Shima H, Sugiyama S, Inaka K, Yamamoto A, Shimizu R, Biochem Biophys Res Commun. 2003 Mar 21;302(4):849-54. PMID:12646248

Page seeded by OCA on Tue Jul 1 14:24:01 2008

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