1j3g

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1j3g.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1j3g.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1j3g| PDB=1j3g | SCENE= }}
{{STRUCTURE_1j3g| PDB=1j3g | SCENE= }}
-
'''Solution structure of Citrobacter Freundii AmpD'''
+
===Solution structure of Citrobacter Freundii AmpD===
-
==Overview==
+
<!--
-
AmpD is a bacterial amidase involved in the recycling of cell-wall fragments in Gram-negative bacteria. Inactivation of AmpD leads to derepression of beta-lactamase expression, presenting a major pathway for the acquisition of constitutive antibiotic resistance. Here, we report the NMR structure of AmpD from Citrobacter freundii (PDB accession code 1J3G). A deep substrate-binding pocket explains the observed specificity for low molecular mass substrates. The fold is related to that of bacteriophage T7 lysozyme. Both proteins bind zinc at a conserved site and require zinc for amidase activity, although the enzymatic mechanism seems to differ in detail. The structure-based sequence alignment identifies conserved features that are also conserved in the eukaryotic peptidoglycan recognition protein (PGRP) domains, including the zinc-coordination site in several of them. PGRP domains thus belong to the same fold family and, where zinc-binding residues are conserved, may have amidase activity. This hypothesis is supported by the observation that human serum N-acetylmuramyl-L-alanine amidase seems to be identical with a soluble form of human PGRP-L.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12654266}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12654266 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12654266}}
==About this Structure==
==About this Structure==
-
1J3G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Citrobacter_freundii Citrobacter freundii]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1j2s 1j2s]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J3G OCA].
+
1J3G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Citrobacter_freundii Citrobacter freundii]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1j2s 1j2s]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J3G OCA].
==Reference==
==Reference==
Line 29: Line 33:
[[Category: Otting, G.]]
[[Category: Otting, G.]]
[[Category: Mixed alpha-beta]]
[[Category: Mixed alpha-beta]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:45:33 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:26:51 2008''

Revision as of 11:26, 1 July 2008

Image:1j3g.png

Template:STRUCTURE 1j3g

Solution structure of Citrobacter Freundii AmpD

Template:ABSTRACT PUBMED 12654266

About this Structure

1J3G is a Single protein structure of sequence from Citrobacter freundii. This structure supersedes the now removed PDB entries and 1j2s. Full experimental information is available from OCA.

Reference

NMR structure of Citrobacter freundii AmpD, comparison with bacteriophage T7 lysozyme and homology with PGRP domains., Liepinsh E, Genereux C, Dehareng D, Joris B, Otting G, J Mol Biol. 2003 Apr 4;327(4):833-42. PMID:12654266

Page seeded by OCA on Tue Jul 1 14:26:51 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1j3g"
Personal tools