1j4m

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[[Image:1j4m.jpg|left|200px]]
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{{Seed}}
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[[Image:1j4m.png|left|200px]]
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{{STRUCTURE_1j4m| PDB=1j4m | SCENE= }}
{{STRUCTURE_1j4m| PDB=1j4m | SCENE= }}
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'''Minimized average structure of the 14-residue peptide RG-KWTY-NG-ITYE-GR (MBH12)'''
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===Minimized average structure of the 14-residue peptide RG-KWTY-NG-ITYE-GR (MBH12)===
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==Overview==
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Here we present a combinatorial approach to evolve a stable beta-hairpin fold in a linear peptide. Starting with a de novo-designed linear peptide that shows a beta-hairpin structure population of around 30%, we selected four positions to build up a combinatorial library of 20(4) sequences. Deconvolution of the library using circular dichroism reduced such a sequence complexity to 36 defined sequences. Circular dichroism and NMR of these peptides resulted in the identification of two linear 14-aa-long peptides that in plain buffered solutions showed a percentage of beta-hairpin structure higher than 70%. Our results show how combinatorial approaches can be used to obtain highly structured peptide sequences that could be used as templates in which functionality can be introduced.
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The line below this paragraph, {{ABSTRACT_PUBMED_11782528}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11782528 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11782528}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J4M OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J4M OCA].
==Reference==
==Reference==
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[[Category: Serrano, L.]]
[[Category: Serrano, L.]]
[[Category: Beta-hairpin]]
[[Category: Beta-hairpin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:47:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:29:32 2008''

Revision as of 11:29, 1 July 2008

Image:1j4m.png

Template:STRUCTURE 1j4m

Minimized average structure of the 14-residue peptide RG-KWTY-NG-ITYE-GR (MBH12)

Template:ABSTRACT PUBMED 11782528

About this Structure

Full experimental information is available from OCA.

Reference

Combinatorial approaches: a new tool to search for highly structured beta-hairpin peptides., Pastor MT, Lopez de la Paz M, Lacroix E, Serrano L, Perez-Paya E, Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):614-9. Epub 2002 Jan 8. PMID:11782528

Page seeded by OCA on Tue Jul 1 14:29:32 2008

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