1j75

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{{STRUCTURE_1j75| PDB=1j75 | SCENE= }}
{{STRUCTURE_1j75| PDB=1j75 | SCENE= }}
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'''Crystal Structure of the DNA-Binding Domain Zalpha of DLM-1 Bound to Z-DNA'''
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===Crystal Structure of the DNA-Binding Domain Zalpha of DLM-1 Bound to Z-DNA===
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==Overview==
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The first crystal structure of a protein, the Z alpha high affinity binding domain of the RNA editing enzyme ADAR1, bound to left-handed Z-DNA was recently described. The essential set of residues determined from this structure to be critical for Z-DNA recognition was used to search the database for other proteins with the potential for Z-DNA binding. We found that the tumor-associated protein DLM-1 contains a domain with remarkable sequence similarities to Z alpha(ADAR). Here we report the crystal structure of this DLM-1 domain bound to left-handed Z-DNA at 1.85 A resolution. Comparison of Z-DNA binding by DLM-1 and ADAR1 reveals a common structure-specific recognition core within the binding domain. However, the domains differ in certain residues peripheral to the protein-DNA interface. These structures reveal a general mechanism of Z-DNA recognition, suggesting the existence of a family of winged-helix proteins sharing a common Z-DNA binding motif.
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The line below this paragraph, {{ABSTRACT_PUBMED_11524677}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11524677 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11524677}}
==About this Structure==
==About this Structure==
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[[Category: Schwartz, T.]]
[[Category: Schwartz, T.]]
[[Category: Protein/z-dna complex]]
[[Category: Protein/z-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:51:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:34:22 2008''

Revision as of 11:34, 1 July 2008

Image:1j75.png

Template:STRUCTURE 1j75

Crystal Structure of the DNA-Binding Domain Zalpha of DLM-1 Bound to Z-DNA

Template:ABSTRACT PUBMED 11524677

About this Structure

1J75 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins., Schwartz T, Behlke J, Lowenhaupt K, Heinemann U, Rich A, Nat Struct Biol. 2001 Sep;8(9):761-5. PMID:11524677

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