1j7n

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{{STRUCTURE_1j7n| PDB=1j7n | SCENE= }}
{{STRUCTURE_1j7n| PDB=1j7n | SCENE= }}
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'''Anthrax Toxin Lethal factor'''
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===Anthrax Toxin Lethal factor===
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==Overview==
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Lethal factor (LF) is a protein (relative molecular mass 90,000) that is critical in the pathogenesis of anthrax. It is a highly specific protease that cleaves members of the mitogen-activated protein kinase kinase (MAPKK) family near to their amino termini, leading to the inhibition of one or more signalling pathways. Here we describe the crystal structure of LF and its complex with the N terminus of MAPKK-2. LF comprises four domains: domain I binds the membrane-translocating component of anthrax toxin, the protective antigen (PA); domains II, III and IV together create a long deep groove that holds the 16-residue N-terminal tail of MAPKK-2 before cleavage. Domain II resembles the ADP-ribosylating toxin from Bacillus cereus, but the active site has been mutated and recruited to augment substrate recognition. Domain III is inserted into domain II, and seems to have arisen from a repeated duplication of a structural element of domain II. Domain IV is distantly related to the zinc metalloprotease family, and contains the catalytic centre; it also resembles domain I. The structure thus reveals a protein that has evolved through a process of gene duplication, mutation and fusion, into an enzyme with high and unusual specificity.
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The line below this paragraph, {{ABSTRACT_PUBMED_11700563}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11700563 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11700563}}
==About this Structure==
==About this Structure==
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[[Category: Mek]]
[[Category: Mek]]
[[Category: Zinc metalloprotease]]
[[Category: Zinc metalloprotease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:53:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:35:52 2008''

Revision as of 11:35, 1 July 2008

Image:1j7n.png

Template:STRUCTURE 1j7n

Anthrax Toxin Lethal factor

Template:ABSTRACT PUBMED 11700563

About this Structure

1J7N is a Single protein structure of sequence from Bacillus anthracis. Full crystallographic information is available from OCA.

Reference

Crystal structure of the anthrax lethal factor., Pannifer AD, Wong TY, Schwarzenbacher R, Renatus M, Petosa C, Bienkowska J, Lacy DB, Collier RJ, Park S, Leppla SH, Hanna P, Liddington RC, Nature. 2001 Nov 8;414(6860):229-33. PMID:11700563

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