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1j7v

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[[Image:1j7v.jpg|left|200px]]
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{{Seed}}
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[[Image:1j7v.png|left|200px]]
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{{STRUCTURE_1j7v| PDB=1j7v | SCENE= }}
{{STRUCTURE_1j7v| PDB=1j7v | SCENE= }}
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'''HUMAN IL-10 / IL-10R1 COMPLEX'''
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===HUMAN IL-10 / IL-10R1 COMPLEX===
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==Overview==
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Interleukin 10 (IL-10) is a dimeric cytokine that plays a central role in suppressing inflammatory responses. These activities are dependent on the interaction of IL-10 with its high-affinity receptor (IL-10R1). This intermediate complex must subsequently recruit the low-affinity IL-10R2 chain before cell signaling can occur. Here we report the 2.9 A crystal structure of IL-10 bound to a soluble form of IL-10R1 (sIL-10R1). The complex consists of two IL-10s and four sIL-10R1 molecules. Several residues in the IL-10/sIL-10R1 interface are conserved in all IL-10 homologs and their receptors. The data suggests that formation of the active IL-10 signaling complex occurs by a novel molecular recognition paradigm where IL-10R1 and IL-10R2 both recognize the same binding site on IL-10.
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The line below this paragraph, {{ABSTRACT_PUBMED_11485736}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11485736 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11485736}}
==About this Structure==
==About this Structure==
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[[Category: Cytokine receptor complex]]
[[Category: Cytokine receptor complex]]
[[Category: Interleukin-10]]
[[Category: Interleukin-10]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:53:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:36:35 2008''

Revision as of 11:36, 1 July 2008

Image:1j7v.png

Template:STRUCTURE 1j7v

HUMAN IL-10 / IL-10R1 COMPLEX

Template:ABSTRACT PUBMED 11485736

About this Structure

1J7V is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site., Josephson K, Logsdon NJ, Walter MR, Immunity. 2001 Jul;15(1):35-46. PMID:11485736

Page seeded by OCA on Tue Jul 1 14:36:35 2008

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